Indium(III) halides catalyze efficiently the intramolecular hydroarylation (IMHA) of aryl propargyl ethers. The reaction proceeds regioselectively with terminal and internal alkynes bearing electron-rich and electron-deficient substituents in the benzenes and alkynes affording only the 6-endo dig cyclization product. Additionally, a sequential indium-catalyzed IMHA and palladium-catalyzed Sonog...

This paper describes a whole cell sensor using E. coli entrapped within photocrosslinked hydrogel beads. Hydrogel beads containing organophosphorus hydrolase (OPH)-expressed E. coli were prepared by adding a hydrogel precursor solution containing the E. coli to an oil phase using a precision syringe pump, forming droplets, and photopolymerizing them. The beads showed good monodispersity with an...

New titanium(IV) complexes having two bidentate β-iminoethyl-spiro[4,5]decan-6-onato ligands with various N-aryl substituents have been synthesized. X-ray crystal structure analysis reveals that these titanium complexes all exhibit a C2-symmetric conformation with a distorted octahedral geometry, although the specific orientation of the ligands around the titanium center varies with the identit...

Cocaine is an environmental contaminant in North America. Benzoylecgonine (BZE) is the major urinary metabolite of cocaine in horses and humans, and urinary detection of BZE is highly sensitive. Human workplace drug testing typically uses a confirmatory “cutoff” for BZE of 150 ng/ml in urine. A number of horse-racing jurisdictions have adopted similar urinary “cutoffs” for BZE; this communicati...

The mechanism of aryl propargyl ether Claisen rearrangement in gas and solvent phase was investigated using DFT methods. Solvent phase calculations are carried out using N,N-diethylaniline as a solvent in the PCM model. The most favorable pathways involve a [3,3]-sigmatropic reaction followed by proton transfer in the first two steps and then deprotonation or [1,5]-sigmatropic reaction. Finally...

Anxiety involves complex, incompletely understood interactions of genomic, environmental, and experience-derived factors, and is currently being measured by psychological criteria. Here, we report previously nonperceived interrelationships between expression variations and nucleotide polymorphisms of the chromosome 7q21-22 acetylcholinesterase-paraoxonase 1 (ACHE-PON1) locus with the trait- and...

Presently, organophosphorus pesticides (OPs) have largely replaced organochlorine compounds in the agricultural activities. Total turnover of OPs has increased around the world. Their residues have been detected in ground and drinking waters (Barceló, 1993), natural surface waters (Hernández et al., 1996), marine organisms (Barceló et al., 1990) and food products (Gunderson, 1995; Dejonkeheer e...

To evaluate the health impact of spraying organophosphorus insecticides (OPs), 34 male sprayers in the mango belt of Malihabad, a small town located 27 km from Lucknow in North India was selected. Plasma butyryl cholinesterase (PBChE) and complete blood count were assessed among sprayers after spraying pesticides and the findings obtained were compared with those determined in a reference group...

AIM It has been known that there was a relation between the activities of serum paraoxonase (PON) and the severity of the coronary artery disease. However, little is known about association of coronary artery calcification (CAC) and serum PON activities. The aim of this study is to evaluate the relationship between CAC and serum PON activities. PATIENTS AND METHODS We measure serum PON activi...

Objective Comparison of the total oxidant status (TOS), total antioxidant status (TAS) and paraoxonase (PON1) serum levels in patients with nasal septum deviation (NSD) and healthy subjects. Methods The TAS, TOS, and PON1 serum levels of 47 patients with NSD (mean age 35.3) and 50 healthy subjects (mean age 37.8) were compared in this study. Results We found significantly higher TAS levels ...