~UklQSE : I~ka Ocular Ptesstire (KM’) veries through out the nycthemeral. Noclutnal sludtes desctibed recehtty an elevation of ltlP dutlttg sleep. Howevet, no lepokt on sleep pstlerns associated nlth Ihe measurement of IOP kds made. WC report hcte, 2 studies ntt haurly measukmenl al IOP over a pertnd ol24 hours. WHODS : Twelve young tdltsnsians subjects (dged 20,6f 0,3 Yeats), lwelvk uldet tdut...

AMONG the various tests used in the early diagnosis of glaucoma the so-called provocative tests occupy an important place. Numerous tests have been proposed, but their reliability on a statistical basis has only been studied in the case of some tests. Not all of these have given clinically satisfactory results, either on account of the variability of their results or of the inconvenience their ...

Many diabetics must measure their blood glucose levels regularly to maintain good health. In principle, one way of measuring the glucose concentration in the human body would be by measuring optically the glucose content of the aqueous humor in the eye. Lein Applied Diagnostics wish to assess whether this is feasible by a linear confocal scan with an LED source, or by supplementing such a syste...

The effect of plasma level of 5, 5-dimethyl-2, 4-oxazolidinedione (DMO) and of inhibitors of aqueous secretion on the distribution of DMO in intraocular fluids has been studied. Plasma levels of DMO from 35 to 60 mg./lOO ml. were required to obtain an appreciable excess of DMO in posterior and anterior aqueous humors compared with plasma. At plasma levels below 20 mg./lOO ml. the concentration ...

A noninvasive method of measuring the concentration of plasma protein in the anterior chamber is described. Fluorescein is applied to the cornea. After the aqueous humor becomes fluorescent, the polarization of fluorescence is measured. The concentration of plasma protein, mainly albumin, can be calculated from the polarization.

The short-term effects on aqueous humor flow dynamics of single doses of acetazolamide and L-epinephrine, alone and combined, were studied in selected young, normal men. Analysis of aqueous flow before and after medication was facilitated, by graphic representation of flow versus intraocular pressure, the flow curve. Acetazolamide reduced intraocular pressure and Pk of Goldmann without affectin...

The levels of cyclic-AMP, cyclic-GMP and betamethasone (BM) in the aqueous humor and serum BM following topical treatment with BM were determined using radioimmunoassay (RIA) methods. One drop of a solution containing 0. 1%, 0. 5% or 1. 0% BM was applied to the rabbit eye of 6 rabbits. The left eyes served as controls. BM was detected in the aqueous humor from right eyes 15 minutes after admini...

Purpose: To compare rate of change in IOP with and without air bubbles in the anterior chamber (AC). Methods: Enucleated porcine eyes were infused with Balanced Salt Solution (BSS) at 10μl/min. In one experiment, 5 eyes each were injected with 0.15 or 0.30ml bubbles without prior removal of aqueous humour while 5 controls were not injected. In another experiment, 9 eyes were injected with 0.30m...

Sixteen patients enrolled in the PERK study were evaluated by fluorophotometry 24 hours or six months following radial keratotomy. A comparison of eyes operated and not operated upon showed that endothelial permeability was not significantly altered 24 hours and six months after surgery. Aqueous humour flow rates and anterior chamber elimination coefficients were significantly higher 24 hours a...

In the time of Galen (13I-20I) the vacant spaces between the cornea and the lens were assumed to be filled with a viscid fluid resembling the white of an egg. It was believed that this tissue-the lens, iris, and cornea-forming the boundary of these spaces was kept from desiccating by this fluid medium. This assumption prevailed for nearly I 300 years until Andreas Vesalius (5 I4-I564) revealed,...