نتایج جستجو برای: antibody sandwich enzyme

تعداد نتایج: 403085  

2017
Ho Bin Seo Man Bock Gu

Sandwich-type biosensor platforms have drawn lots of attentions due to its superior features, compared to other platforms, in terms of its stable and reproducible responses and easy enhancement in the detection sensitivity. The sandwich-type assays can be developed by utilizing a pair of receptors, which bind to the different sites of the same target. In this mini-review paper, the sandwich-typ...

Journal: :Mediators of inflammation 2016
Lang Yi Mingju Hao Tian Lu Guigao Lin Lida Chen Ming Gao Gaowei Fan Dong Zhang Guojing Wang Xin Yang Yulong Li Kuo Zhang Rui Zhang Yanxi Han Lunan Wang Jinming Li

The κ/λ hybrid antibodies in normal human serum were reported recently, but their clinical relevance has not yet been explored. Rheumatoid arthritis (RA) is one of the major joint diseases, and the early diagnosis and treatment of RA remain a challenge. Here, we developed a double-sandwich enzyme-linked immunosorbent assay system to quantify relative serum κ/λ hybrid antibody levels in RA patie...

Journal: :Journal of clinical microbiology 1987
S Khusmith S Tharavanij R Kasemsuth C Vejvongvarn D Bunnag

Three systems of immunoradiometric assays (IRMAs), a two-site monoclonal antibody sandwich IRMA (MAb-IRMA), two-site polyclonal antibody-monoclonal antibody sandwich IRMA (PAb-MAb-IRMA), and two-site polyclonal antibody sandwich IRMA (PAb-IRMA), were developed to detect low-grade infections with Plasmodium falciparum. The assays showed good correlation with parasitemia when tested against paras...

2013
Kaori Abe Yoshiko Hashimoto Shouki Yatsushiro Shohei Yamamura Mika Bando Yuka Hiroshima Jun-ichi Kido Masato Tanaka Yasuo Shinohara Toshihiko Ooie Yoshinobu Baba Masatoshi Kataoka

Sandwich enzyme-linked immunosorbant assay (ELISA) using a 96-well plate is frequently employed for clinical diagnosis, but is time-and sample-consuming. To overcome these drawbacks, we performed a sandwich ELISA on a microchip. The microchip was made of cyclic olefin copolymer with 4 straight microchannels. For the construction of the sandwich ELISA for interleukin-6 (IL-6) or tumor necrosis f...

2015
Zhijun Zhang Yijia Guan Meng Li Andong Zhao Jinsong Ren Xiaogang Qu

Sandwich ELISA methods have been widely used for biomarker and pathogen detection because of their high specificity and sensitivity. However, the main drawbacks of this assay are the cost, the timeconsuming procedure for the isolation of antibodies and their poor stability. To overcome these restrictions, we herein fabricated artificial antibodies based on imprinting technology and developed a ...

Journal: :Chemical science 2015
Zhijun Zhang Yijia Guan Meng Li Andong Zhao Jinsong Ren Xiaogang Qu

Sandwich ELISA methods have been widely used for biomarker and pathogen detection because of their high specificity and sensitivity. However, the main drawbacks of this assay are the cost, the time-consuming procedure for the isolation of antibodies and their poor stability. To overcome these restrictions, we herein fabricated artificial antibodies based on imprinting technology and developed a...

Journal: :Journal of clinical microbiology 1989
C Edwin

A sandwich enzyme-linked immunosorbent assay to detect staphylococcal enterotoxin A (SEA) was developed by using monoclonal antibodies (MAb) to SEA as primary capture antibodies. The antigen was detected with purified rabbit anti-SEA antibody as the secondary antibody. The secondary antibody was identified by direct conjugation with biotin or via biotinylated sheep F(ab')2 fragments to rabbit a...

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