نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

اسعدی, حانیه, توکلی, احمد, صفرنژاد تمشکل, فهیمه, فروغی نیا, بهروز, کربلائی نیا, محمد هادی, کیوانی, حسین,

Hepatitis C virus (HCV) infection has affected approximately 180 million people across the world. In most cases, HCV-infection remains chronic, which expose patients at high risk of cirrhosis and hepatocellular carcinoma. The rates of disease incidence and mortality diminish as a result of successful treatment of HCV infection. Until the recent years, despite the associated toxicities and l...

Journal: :Folia histochemica et cytobiologica 2007
Aldona Kasprzak Agnieszka Adamek Wieslawa Biczysko Jolanta Seidel Wieslawa Przybyszewska Karolina Olejniczak Jacek Juszczyk Maciej Zabel

Hepatitis C virus (HCV) continues to represent the main causative agent of the hepatitis, which leads to chronic transformation of the process in 60-80% individuals. It remains unclear how far cellular expression of HCV proteins in vivo may represent an index of progression of the disease and of proliferative activity in the liver in chronic hepatitis C. Aim of the studies included detection an...

2018
Markus M Knodel Arne Nägel Sebastian Reiter Andreas Vogel Paul Targett-Adams John McLauchlan Eva Herrmann Gabriel Wittum

Exploring biophysical properties of virus-encoded components and their requirement for virus replication is an exciting new area of interdisciplinary virological research. To date, spatial resolution has only rarely been analyzed in computational/biophysical descriptions of virus replication dynamics. However, it is widely acknowledged that intracellular spatial dependence is a crucial componen...

2018
Ryuichi Sugiyama Asako Murayama Sayuri Nitta Norie Yamada Megumi Tasaka-Fujita Takahiro Masaki Hussein Hassan Aly Masaaki Shiina Akihide Ryo Koji Ishii Takaji Wakita Takanobu Kato

The number of amino acid substitutions in the interferon (IFN) sensitivity-determining region (ISDR) of hepatitis C virus (HCV) NS5A is a strong predictor for the outcome of IFN-based treatment. To assess the involvement of ISDR in the HCV life cycle and to clarify the molecular mechanisms influencing IFN susceptibility, we used recombinant JFH-1 viruses with NS5A of the genotype 1b Con1 strain...

Journal: :The Journal of general virology 2005
Katerina I Kalliampakou Maria Kalamvoki Penelope Mavromara

Translation of the hepatitis C virus (HCV) polyprotein is mediated by an internal ribosome entry site (IRES) that is located mainly within the 5' non-translated region of the viral genome. In this study, the effect of the HCV non-structural 5A (NS5A) protein on the HCV IRES-dependent translation was investigated by using a transient transfection system. Three different cell lines (HepG2, WRL-68...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس 1387

مقدمه: ویروس هپاتیت c یکی از عوامل اصلی ایجاد بیماری مزمن کبدی و سرطان کبد است. درمان ترکیبی با پگ اینترفرون و آنالوگ نوکلئوزیدی ریباویرین در بسیاری از بیماران منجر به پاکسازی ویروس می شود. یکی از ژن های القاء شده توسط اینترفرون ، پروتئین کیناز r است. تاثیر ضد ویروسی این پروتئین به علت تعامل با یکی از عوامل شروع ترجمه به نام eif2? و در نتیجه ممانعت از سنتز پروتئین می باشد. به نظر می رسد پروتئین...

2014
Katarzyna Gawlik James Baugh Udayan Chatterji Precious J. Lim Michael D. Bobardt Philippe A. Gallay

Hepatitis C virus (HCV) infection is a major cause of liver disease. The molecular machinery of HCV assembly and particle release remains obscure. A better understanding of the assembly events might reveal new potential antiviral strategies. It was suggested that the nonstructural protein 5A (NS5A), an attractive recent drug target, participates in the production of infectious particles as a re...

Journal: :Journal of viral hepatitis 2002
G Squadrito G Raffa T Restuccia T Pollicino S Brancatelli G Raimondo

Nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) may repress the interferon (IFN)-induced protein kinase R (PKR). High variability of different regions in the carboxy-terminal half of NS5A implicated in the interaction with PKR (particularly the interferon sensitivity determining region (ISDR)) may be a predictor of response to IFN in patients infected with genotype 1b of HCV. We ...

Journal: :Antiviral therapy 2012
Zulema Plaza Vincent Soriano Eugenia Vispo Maria del Mar Gonzalez Pablo Barreiro Eduardo Seclén Eva Poveda

BACKGROUND Daclatasvir (BMS-790052) is an investigational molecule that inhibits the HCV NS5A protein and shows potent antiviral activity apparently across all HCV genotypes. Selection of drug resistance mutations has been reported only for HCV genotype 1, and no information exists for other HCV variants and/or in HIV-HCV-coinfected individuals. METHODS All interferon-α-naive, HIV-HCV-coinfec...

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