programmed cell death, which can be classified into apoptosis, autophagy, and oncosis, based on the cellular signalling pathways involved in the process, plays a critical role in cellular house-keeping. aberrant cell death regulation leads to body malformations, as well as to numerous diseases. here, we describe the effects of cytototoxins isolated from marine organisms on the various programme...

background today, the use of cyclodextrins (cds) is a major concern in drug formulations to improve solubility and stability of compounds. it has been known that cds can reduce the antimicrobial effectiveness of preservatives by formation of inclusion complexes. objectives in this study the interaction between commonly used preservatives, benzalkonium chloride (bzcl) or methyl paraben (mp), wit...

cancer is a major global problem and is the second leading cause of mortality in the developed countries.resistance to current chemotherapeutics and high incidence of adverse effects are the two principal reasons for developing new anticancer agents. phenylacetamide derivatives can act as potential anticancer agents. synthesis and screening of 2-(4-fluorophenyl)-n-phenylacetamide derivatives in...

halophilic bacteria grow over a wide range of salt concentrations. in this study we aimed to isolate and screen out the halophilic bacteria and to determine their activity for production of the bioactive compounds. a total of 50 water, sediments and soil samples were collected from maharlu salt lake in southern region of fars-iran and subjected for isolation of the bioactive compound producing ...

Background: Cyanobacteria have a worldwide distribution in the terrestrial habitats, occurring predominantly on the surface of the soils, stones, rocks, and trees, practically in moist, neutral or alkaline aeries. The unique natural and bioactive compounds from cyanobacteria with various biological activities and an extensive range of chemical classes have a significant capabil...

Leishmaniasis is a neglected public health problem caused by the protozoan species belonging to the genus Leishmania affecting mostly the poor populations of developing countries. The causative organism is transmitted by female sandflies. Cutaneous, mucocutaneous, and visceral clinical manifestations are the most frequent forms of leishmaniasis. Chemotherapy still relies on the use of pentavale...

Background & Aim: Fabaceae plant family cow tail (Smirnovia iranica) is one of the valuable species of native shrubs and sand dunes in the central region of Iran which is consistent with the production of forage and soil conservation and creating a beautiful landscape; it has the active ingredients of medicinal values. The purpose of this study was to investigate the presence of some p...

In this study, the effects of different concentrations of silica nanoparticles (NPs) were studied on growth, membrane stability, and antioxidant properties of Matricaria chamomilla in vitro. The sterilized seeds were incubated in different concentrations of silica NPs (0, 2, 4, 6 g L-1<span st...

In the combination of 5-fluorophenyl-1, 3, 7, 9-tetra methyl pyrido [2, 3, d, d, 5, 6 di pyrimidine -2, 4, 6, and 8 tetron, there are 4 rings, respectively, ring that is attached to the halogen ring A and, respectively, a ring The lower and the right to the left of the ring A are called C, B, and D. Calculations and studies show that the amount of aromatics in halogen-ring A in all cases has th...