The concept of acute-on-chronic liver failure (ACLF) was introduced recently to describe a subset of patients with chronic liver disease presenting with profound deterioration of liver function and rapidly evolving multi-organ failure. ACLF is frequently accompanied by the development of severe inflammatory response syndrome and has a high mortality. To date, treatment options are limited and e...

The longer survival of liver transplant recipients has emphasized the need to consider complications that develop several years after liver transplantation, such as chronic renal dysfunction. Renal dysfunction has an impact on long-term posttransplant morbidity and mortality. The prevalence of chronic renal disease among liver transplant recipients varies widely from 10 to 78%. This renal dysfu...

INTRODUCTION Thyroid storm is an endocrinological emergency caused by an exacerbation of the hyperthyroid state and is characterized by multi organ dysfunction. Liver dysfunction or injury predominantly of a cholestatic type is one of the atypical manifestations of thyroid storm and has been previously described in literature. However, there have been few published case reports among African pa...

INTRODUCTION Acute hepatitis due to hepatitis a virus is usually a benign self-limiting disease conferring lifelong immunity. However, few cases have been reported in literature with fulminant hepatitis. We report this extremely rare case with multiorgan dysfunction including liver failure, hepatic encephalopathy, renal failure, pleural effusion, pericardial effusion and hematologic dysfunction...

463 Liver failure occurs either as acute liver failure (ALF) developing de novo or as acute decompensation of chronic liver disease (ACLF). The clinical manifestations are fairly similar characterised by multiorgan dysfunction characterised by encephalopathy (HE), hypotension, and renal failure (HRS).1,2 Unlike chronic decompensation of end-stage liver disease, ALF and ACLF are potentially reve...

background: interleukin-17 (il-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. however, there is not much information about the effects of il-17 cytokine on acute liver rejection. objective: to evaluate the role of il-17 in post-liver transplant acute rejection. methods: ninety seven adult liver transplant patients who enrolled in this cross sec...