In order to investigate the potential of a Sanguisorba officinalis root extract as an active ingredient for wrinkle-care cosmetics, we measured its free radical scavenging activity, elastase inhibitory activity, expression of MMP-1 (matrix metalloprotease-1) in vitro, and type I collagen synthesis in normal human fibroblast cells. To isolate the main components from the S. officinalis root extr...

the physicochemical properties of Iranian acetyl salicylic acid(ASA) tablets,including the products of 10 manufacturers with 14 products,from each 3 batches,totally 42 products have been studied.the properties under investigation are hardness,friability percintage,humidity percentage,free salicylic acid,content uniformity,amount of ASA disintegration time,and released percentage.the results ind...

The design of retaining walls depends on the magnitude of active pressure exerted from the backfill. Therefore, estimating the scale of this pressure is a fundamental factor in the design. In this study, to assess the active earth pressure, a rigid retaining wall was built capable of translating and/or rotating with adjustable speed. Further, several physical tests were conducte...

There may be substantial differences in the chemical composition of technical-grade products of the same active ingredient manufactured under different conditions, from different raw materials, or by different routes of synthesis. Resulting differences in impurity content may significantly affect the toxicological properties of pesticide products. Relevant impurities are those that may exhibit ...

The »Formulating for Efficacy« concept is a systematic approach to simultaneously optimize the driving force of the active ingredient (so that it partitions in larger quantities into the stratum corneum) and reduce its concentration in the formulation without a loss of clinical efficacy. Its ultimate aim is to optimize the clinical efficacy via enhancement of the skin delivery of the active pri...

A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens (0.5 mg, 2 mg, and 6 mg daily) for one month. The objectives of present study were to (i) prepare low-dose melatonin hard capsules for pediatric use controlled by two complementary methods and (ii) carry out a stabilit...