The pharmacokinetic parameters of ceftriaxone in eight patients with end-stage renal disease were determined during dialysis and during the interdialysis period. The mean half-life, clearance, and apparent volume of distribution during dialysis were 16 h, 722 ml/h, and 16.7 liters, respectively. During the interdialysis period, the half-life was 14 h, clearance was 739 ml/h, and volume of distr...

I Decary F, Fermer P, Giaredoni L, et al. An investigation of nonhaemolvtic transfusion reactions. Vox Sang 1984;46:277-85. 2 Moore SB, Taswell HF, Pineda AA, Sonnenberg CL. Delayed hemolytic transfusion reactions. Am7 Clin Pathol 1980;74:94-7. 3 Laskv LC, Rose RR, Poleskv HF. Incidence of antibody formation and positive direct antiglobulin tests in a muiltitransfuscd hemodialysis population. T...

According to the World Health Organization, infectious diseases account for more than 13 million deaths every year, including nearly two-thirds of all deaths among children under age 5. Although the great majority of these deaths occur in developing countries, infectious diseases do not recognize international boundaries. They present a substantial threat to people in all parts of the world. In...

19 Brock, T. D., Science, 129, 960 (1959). 20 Clamp, J. R., and L. Hough, Biochem. J., 94, 17 (1965). 21 Vidaver, A. M. K., Ph.D. dissertation, Indiana University, Bloomington (1965). 22 Stahl, E., and U. Kaltenbach, J. Chromatog., 5, 351 (1961). 23Falcone, G., and W. J. Nickerson, Science, 124, 272 (1956). 24 Nickerson, W. J., and G. Falcone, Science, 124, 318 (1956). 25Ibid., p. 722. 26 Lampe...

SUMMARY Two studies published in this issue of Cancer Discovery describe the emerging mutational landscape of head and neck squamous cell carcinomas (HNSCC) and their genomic and epigenetic alterations, thus identifying novel actionable cancer drivers and predictive biomarkers for targeted therapies. Most genomic alterations in HNSCC converge in a handful of molecular pathways, resulting in cel...

We aimed to identify bacterial pathogens/contaminants in dairy product samples collected by environmental health inspectors of the Palestinian Ministry of Health from 2001-04. A total of 722 samples of dairy products were randomly collected from different sources in Ramallah and Al-Bireh district. The percentages of unacceptable samples for the combined years were: 23.0% for total aerobic count...

Methods We investigated adiponectin receptor 1(AdipoR1) gene rs10920533 associated with non-HDL-C(case: 109 subjects with high non-HDL-C; control: 701 subjects with normal non-HDL-C); apolipoprotein A5(ApoA5) gene -1131T>C and -3A>G associated with TG(case: 245 subjects with high TG; control: 595 subjects with normal TG); glucocorticoid receptor(GR) gene rs12521436 associated with HDL-C(case: 1...