PSC, which is stellate or fusiform, relatively rare, accounting for only 4%-7% of the total number pancreatic cells. In 1982, Japanese scholars [1] found a kind cells with vitamin A storage function similar to hepatic in mouse pancreas.

objective(s): up to now, many researches have been performed to improve the antitumoral effect of melanoma differentiation-associated gene-7 (mda-7) protein. the purpose of our research was to construct 3 expression vectors producing mda-7 in fusion with rgd (arginine-glycine-aspartic acid) peptide and evaluate their expression.     materials and methods: mda-7 gene with two different rgd seque...

backgrounds: evidence is accumulating to support disruption of tissue architecture as a powerful event in tumor formation. for the past four decades, intensive cancer research with the premise of “cancer as a cell based-disease” focused on finding oncogenes or tumor suppressor genes. however, the role of the tissue architecture was neglected. three dimensional (3d) cell cultures which can recap...

Background: Molecular targeted therapy by different cell death inducers are recently considered in cancer therapy. The aim of this study was to compare the effect of cisplatin and inositol trisphosphate kinase inhibitor (caffeine) on human breast cancer cell line (MCF-7). The pattern of cell death in MCF-7 cells following the exposure to cisplatin and caffeine in individual and combination form...

Background and Objectives: The inability of classic fluorescence-activated cell sorting to single cancer cell sorting is one of the most significant drawbacks of this method. The sorting of cancer cells in microdroplets significantly influences our ability to analyze cancer cell proteins. Material and Methods: We adapted a developed microfluidic device as a 3D in vitro model to sorted MCF-7 c...

introduction : deproteinized bovine bone mineral (bio-oss) is a xenogenic bone substitute, widely used in maxillofacial bone regeneration. the aim of this in vitro study was to investigate its influence on the growth behavior of human osteosarcoma cell line, saos-2 culture, and compare it with the physiologic dose of dexamethasone, an inductive factor for osteoblasts. materials and methods: hum...