نتایج جستجو برای: 3 d pyrimidines

تعداد نتایج: 2219499  

Journal: :Journal of the American Chemical Society 1921

Journal: :The Journal of biological chemistry 1952
D V N REDDY M E LOMBARDO L R CERECEDO

The chemical changes occurring during embryonic development have been studied by several workers (l-3). In the hen’s egg there is very little nucleic acid present, whereas a considerable synthesis of both desoxypentose nucleic acid (DNA) and ribose nucleic acid (RNA) occurs in the embryo (4-6). Recently, methods for the determination of purines and pyrimidines in small amounts of tissue have be...

Journal: :Bioorganic & medicinal chemistry letters 2008
Guobao Zhang Pingda Ren Nathanael S Gray Taebo Sim Yi Liu Xia Wang Jianwei Che Shin-Shay Tian Mark L Sandberg Tracy A Spalding Russell Romeo Maya Iskandar Donald Chow H Martin Seidel Donald S Karanewsky Yun He

A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src kinase family. Highly efficient parallel syntheses were devised to prepare analogues for SAR studies. A number of these 4-amino-6-benzimidazole-pyrimidines exhibited single-digit nanomolar IC(50)s against Lck in biochemical and cellular assays. These 4-amino-6-be...

Journal: :Acta pharmaceutica 2013
Mohammed Afzal Azam Loganathan Dharanya Charu Chandrakant Mehta Sumit Sachdeva

In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2- yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1- (1,3-benzothiazol-2-yl)-4-(4-chlorop...

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