In this study, some novel mono- and di-O-β-D-glycopyranosyl chalcone analogs were designed, synthesized, characterized. The derivatives synthesized with good yields by base-catalyzed Claisen-Schmidt condensation in EtOH solution. Then these chalcones reacted TAGBr (2,3,4,6-tetra-O-acetyl-μ-D-glucopyranosylbromide) dry acetone under the anhydrous condition at 0-5 °C. Deacylated was carried out Z...

A dramatic shift in microbial reefs occurred around the Ediacaran–Cambrian boundary. Here we describe changes composition, construction, and texture of Zavkhan Terrane Gobi-Altai Province, western Mongolia, during late Ediacaran early Cambrian. Stromatolites consisting peloids, micritic clots, homogeneous lime mud without calcified microbes (calcimicrobes) are characteristic upper (units 9 16A ...

We characterized the NADPH-dependent metabolism of 17bestradiol (E2) by liver microsomes from 21 male and 12 female human subjects. A large number of radioactive estrogen metabolite peaks were detected following incubations of [H]E2 with male or female human liver microsomes in the presence of NADPH. The structures of 18 hydroxylated or keto estrogen metabolites formed by these microsomes were ...

Thus, the changes in maternal steroid metabolism caused by cholestasis are reflected in the steroid profile of the fetoplacental circulation. Furthermore, maternal intrahepatic cholestasis may result in the production of some substance which crosses the placenta and affects fetal steroid metabolism. Received for publication 7 November 1973 and in revised form 13 February 1974. INTRODUCTION Intr...

Methoxymorpholinyl doxorubicin (MMDX; PNU 152243) is a promising doxorubicin derivative currently undergoing clinical evaluation. Previous in vitro studies suggested that the compound undergoes hepatic biotransformation by cytochrome P450 (CYP) 3A into a more cytotoxic metabolite(s). The present study examined the role of CYP3A-mediated metabolism in the in vivo antitumor activity and host toxi...

The detection of disk-integrated polarization from Luhman 16A and B in H-band, subsequent modeling, has been interpreted the framework zonal cloud bands on these bodies. Recently, Tan Showman (2021) investigated three-dimensional atmospheric circulation structures brown dwarfs with general models (GCMs), their simulations yield complex distributions showing some aspects jets, but also vortices ...