Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and oc...

The vitamin D-3 receptor (VDR) is a nuclear receptor that modulates gene expression when complexed with its ligand 1-a,25-dihydroxycholecalciferol [1,25(OH)2-D3], which is the biologically active form of vitamin D-3. The cellular effects of VDR signaling include growth arrest, differentiation and/or induction of apoptosis, which indicate that the vitamin D pathway participates in negative-growt...

introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with mult...

vitamin d deficiency is a worldwide epidemic, with well known impacts on calcium metabolism and bone health, but increasingly recognized associations with chronic health problems such as bowel and colonic cancer, arthritis, diabetes and cardiovascular disease. in recent years in the sports medicine literature, there has been an increased focus on the potential impact that inadequate vitamin d l...

1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3); 1,25-dihydroxycholecalciferol or calcitriol] is the active form of vitamin D(3), a lipid-soluble vitamin that plays a role in calcium and bone metabolism. Recently, vitamin D(3) has been shown to function in cancer prevention, immunity and cardiovascular regulation. 1,25(OH)(2)D(3) exhibits physiological and pharmacological effects by activating the ...

Humans have the ability to synthesize vitamin D during the action of ultraviolet (UV) radiation upon the skin. Apart from the regulation of calcium and phosphate metabolism, another critical role for vitamin D in immunity and respiratory health has been revealed, since vitamin D receptors have also been found in other body cells. The term "vitamin D insufficiency" has been used to describe low ...

normal 0 false false false en-us x-none ar-sa background: nowadays vitamin d deficiency is a notable medical condition world-wide and also in iran. since, vitamin d can have reoprotective effect by inhibiting the renin-angiotensin system; it appears that low vitamin d level can worsen the renal injury in diabetic patients. this study demonstrates the effect of vitamin d 3 therapy on reducing pr...

SEE PAGE 2593 I dentifying effective pharmacologic and mechanical therapies for heart failure has been an active and costly endeavor in the past several decades. Significant progress has been made, but the morbidity and mortality from this syndrome continues to be unacceptably high. Thus, it would be an exciting development if a relatively simple intervention such as vitamin D supplementation w...

Vitamin D dependent rickets (VDDR) type 2 is a very rare hereditary disease which has an autosomal recessive mode of inheritance. Patients with VDDR have mutation in the gene encoding for vitamin receptor on chromosome 12q12-q14, thus averting normal physiological action 1,25 D. It's presents developmental delay motor domain features usually first year life. Alopecia totalis frequent associatio...

Background Vitamin D deficiency is common in women with PCOS. Vitamin D is thought to influence the development of PCOS through gene transcription, and hormonal modulation influences insulin metabolism and fertility regulation. Therefore, the aim of this review article is to study the effects of vitamin D supplementation in reproductive function of PCOS women. MaterialsAndMethods This review ar...