Introduction: Selaginella species have been used widely for the treatment of inflammatory diseases, diabetes and cancer. In this study, the contents of the total flavonoids and amentoflavone in five Selaginella plant drugs [Selaginella moellendorffii Hieron. (SM), Selaginella delicatula (Desv.) Alston (SD), Selaginella uncinata (Desv.) Spring (SU), Selaginella heterostachys Baker (SH) and Selag...

Recently, a new universal HPLC detection technology has been developed based on charged aerosol detection that has led to the development of a universal HPLC detector, the Corona CAD. To further understand the capabilities of charged aerosol detection and the use of the technology in an HPLC detector, the Corona CAD was tested for its sensitivity, dynamic range, response from compounds of diffe...

A multicomponent pharmaceutical that contains loratadine, paracetamol, and pseudoephedrine was quantified using HPLC-PDA. The three analytes were well-separated in the dosage form on a C-18 column gradient mobile phase. quality by design strategy followed to achieve challenging separation. Screening optimization steps carried out investigate effect of many factors studied responses with minimum...

This paper describes a novel method of sample preparation for the determination of trace concentrations of polycyclic aromatic hydrocarbons (PAHs) in high-boiling petroleum products. Limits of quantitation of the investigated PAHs in materials of this type range from tens of nanograms per kilogram to <20 μg/kg. The studies revealed that in order to separate most of interferences from the analyt...

introduction: the mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. the effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. to further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14c] clozapine with suitable ra...

Nowadays consumers and the food trade increasingly interested in the geographical origin quality of food products. Authentication origins of wine has become a more important task than ever The best determination of the region of origin is possible on the basis of the analytical profile of wine. made to find useful chemical markers, based on the analysis of individual phenolic antioxidants and t...

Quantification of substances such as drug impurities or library compounds when pure standards are unavailable is difficult yet often necessary. This is often accomplished by HPLC based on relative response using low wavelength UV detection. The dependence of response on the optical properties of each component can lead to large errors in estimated quantity. Charged aerosol detection is a mass s...

A technique to detect residual tetracyclines (TCs) in honey by HPLC and derivative UV-Vis spectra is examined in this study. Chromatograms of honey products often experience overlapped peaks and sloping background due to similar retention properties of components or to the presence of impurities. The derivatives provide resolution of overlapped peaks in an UV-Vis spectrum and eventually bring c...