The synthetic investigation of biologically active natural compounds serves two main purposes: (i) the total synthesis of alkaloids and their analogues; (ii) modification of the structures for producing more selective, more effective, or less toxic derivatives. In the chemistry of dimeric Vinca alkaloids enormous efforts have been directed towards synthesizing new derivatives of the antitumor a...

Vinorelbine (5'-noranhydrovinblastine) is a new semisynthetic antineoplastic vinca alkaloid which interfers with axonal transport, inducing spiralisation of axonal microtubules and resulting in peripheral neurotoxicity. A prospective detailed neurological and electrophysiological evaluation was performed in 23 patients treated with 25 mg vinorelbine a week. All patients developed a sensory-moto...

The Effects of Two Alkaloids Derived from Vinca rosea on the Malignant Cells of Hodgkin’s Disease, Lymphosarcoma and Acute Leukemia in Vivo Alberto M. Marmont and Eugenio E. Damasio 1 Studies of Lymphocyte Kinetics in Man Seymour Perry, George L. Irvin, 111, and Jacqueline Whang 22 The Effects of Allografts of Thymic Epithelial Reticular Cells on the Lymphoid Tissues of Neonatally Thymectomized...

Hechang Lei ( ),1 Emil S. Bozin,1 A. Llobet,2 V. Ivanovski,3 V. Koteski,3 J. Belosevic-Cavor,3 B. Cekic,3 and C. Petrovic1 1Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Uptown, New York 11973, USA 2Lujan Neutron Scattering Center, Los Alamos National Laboratory, MS H805, Los Alamos, New Mexico 87545, USA 3Institute of Nuclear Sciences Vinca, Univers...

We present a comparison of the energetics of spiral formation for two vinca alkaloids: a novel difluorinated vinorelbine derivative 20',20'-difluoro-3',4'-dihydrovinorelbine (F12158, or vinflunine) and the parent compound, vinorelbine. Vinca alkaloids are antineoplastic agents that halt cell division at metaphase by inhibiting microtubule assembly and inducing tubulin self-association into spir...