نتایج جستجو برای: transcription factor foxp3

تعداد نتایج: 986123  

2016
Jian-Fei Tu Ya-Hui Ding Xi-Hui Ying Fa-Zong Wu Xin-Mu Zhou Deng-Ke Zhang Hai Zou Jian-Song Ji

Hepatocellular carcinoma (HCC) is a common malignant tumour, especially in Asia. Its prognosis is poor, and there are limited methods for predicting patient survival. This study was carried out to analyse the prognostic value of tumour-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in HCC patients. TILs were analysed in 57 randomly selected HCC patients. The prognostic ...

Journal: :Journal of immunology 2009
Susan Kohlhaas Oliver A Garden Cheryl Scudamore Martin Turner Klaus Okkenhaug Elena Vigorito

Foxp3 is a transcription factor that is essential for the normal development of regulatory T cells (Tregs). In the absence of microRNAs (miRNAs), Foxp3(+) Tregs develop but fail to maintain immune homeostasis, leading to a scurfy-like disease. Global analysis of the network of genes regulated by Foxp3 has identified the miRNA miR-155, which is highly expressed in Tregs, as a direct target of Fo...

Journal: :Microbes and infection 2009
Ryo Takayanagi Takashi Ohashi Hisatoshi Shida

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia (ATL). Some ATL cells express Foxp3, which is known as regulatory T cell (Treg cell) specific transcription factor. It is suggested that Treg cell like suppressive activity of Foxp3 expressing ATL cells is associated to ATL development and related immunodeficiency. To develop an HTLV-1 model system that ...

Journal: :Journal of immunology 2012
Eyad Elkord

The transcription factor Helios has been reported to be a marker of regulatory T cells (Treg) of thymic origin, distinguishing them from Treg induced in the periphery (iTreg). In this study, we demonstrate Helios expression in Foxp3(+) iTreg, both in vitro and in vivo. Following i.v. peptide injection, in vivo Helios expression in adoptively transferred TCR transgenic T cells was more rapid tha...

2016
Fan Wang Xiaojie Lin Mi Xiao Rujuan Chen Muhammad Siddiq Li Liu

To evaluate the effects of regulatory T cells (Tregs) on the placental inflammatory response in a lipopolysaccharide (LPS)-induced preterm birth mouse model. An LPS-induced preterm birth mouse model was established. Tregs were isolated from pregnant mice and injected into different pregnant mice before LPS treatment. The expression levels of fork head family transcription factor (Foxp3), leukem...

2013
Mia Kim Tanja Grimmig Martin Grimm Maria Lazariotou Eva Meier Andreas Rosenwald Igor Tsaur Roman Blaheta Uwe Heemann Christoph-Thomas Germer Ana Maria Waaga-Gasser Martin Gasser

BACKGROUND Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also allow them to evade from effector T-cell responses, resulting in a survival benefit of the tumor. For colorectal cancer (CRC) the clinical rele...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Makoto Miyara Driss Chader Edouard Sage Daisuke Sugiyama Hiroyoshi Nishikawa Diane Bouvry Laetitia Claër Ravi Hingorani Robert Balderas Jurg Rohrer Noel Warner Alain Chapelier Dominique Valeyre Reiji Kannagi Shimon Sakaguchi Zahir Amoura Guy Gorochov

CD4(+) regulatory T (Treg) cells expressing CD25 and the transcription factor forkhead box P3 (FOXP3) are indispensable for immunological self-tolerance and homeostasis. FOXP3(+)CD25(+)CD4(+) T cells in humans, however, are heterogeneous in function and differentiation status, including suppressive or nonsuppressive cells as well as resting or activated Treg cells. We have searched for cell sur...

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