CD4(+) T cells play a critical role in generating and maintaining immune responses against pathogens and alloantigens, and evidence suggests an important role for them in antitumor immunity as well. Although major histocompatibility complex class II-restricted human CD4(+) T cells with specific antitumor reactivities have been described, no standard method exists for cloning the recognized tumo...

The parasite Plasmodium falciparum is responsible for the major world scourge malaria, a disease that affects 3.3 billion people worldwide. The development of new drugs is critical because of the diminished effectiveness of current antimalarial agents mainly due to parasitic resistance, side effects and cost. Molecular docking was used to explore structural motifs responsible for the interactio...

An assay that uses heminested PCR-restriction fragment length polymorphism analysis for the detection and genotyping of Giardia duodenalis on the basis of polymorphism in the triose phosphate isomerase (tpi) gene was developed. This assay was evaluated with DNA extracted from purified parasite material, bacterial cultures, whole human feces containing G. duodenalis and other parasites, and thei...

Abstract This paper puts forward a proposal to complete the ECB Transmission Protection Instrument (TPI) with aim of making it more effective in anchoring yields European sovereign debts Member States’ fundamentals. We use model which fluctuate within bands, we specify following two alternative approaches: stochastic and deterministic. The resulting fluctuation's interval represents range that ...

The observation of the Hong–Ou–Mandel (HOM)-type two-photon interference (TPI) has played an important role in development photonic quantum technologies. time-resolved coincidence-detection technique been effectively used to identify and characterize TPI phenomena long-coherence optical fields. Here, we report on experimental demonstration two phase-randomized weak coherent pulses with coincide...

Software test process improvement (STPI) approaches are frameworks that guide software development organizations to improve their software testing process. We have identified existing STPI approaches and their characteristics (such as completeness of development, availability of information and assessment instruments, and domain limitations of the approaches) using a systematic literature revie...

We examined levels and patterns of nucleotide variation in 21 strains of Drosophila kikkawai from Miyako island, Japan for the partial regions of the following seven nuclear genes: Adh, Ddc, esc, ksr, Pgi, su(f), and Tpi. The nucleotide variation at total sites (pi(t)) ranged from 0.0013 in the ksr, to 0.0173 in the Adh. The nucleotide divergence at total sites (K(t)) between D. kikkawai and D....

Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Because of the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique ...

Three dimensional terahertz pulsed imaging (TPI) was evaluated as a novel tool for the nondestructive characterization of different solid oral dosage forms. The time-domain reflection signal of coherent pulsed light in the far infrared was used to investigate film-coated tablets, sugar-coated tablets, multilayered controlled release tablets, and soft gelatin capsules. It is possible to determin...