Sézary syndrome (SS) is an aggressive, leukemic cutaneous T-cell lymphoma variant. Molecular pathogenesis of SS is still unclear despite many studies on genetic alterations, gene expression and epigenetic regulations. Through whole genome and transcriptome next generation sequencing nine Sézary syndrome patients were analyzed in terms of copy number variations and rearrangements affecting gene ...

A series of benzylamides of N-alkylated, N-acylated or free nine cyclic and one linear amino acids as potential anticonvulsants have been synthesized. The structures of the obtained compounds were designed on the basis of the previously determined structure and physicochemical properties/anticvonvulsant activity relationship of the formerly synthesized compounds of this type. The obtained compo...

In the domain of concurrent object-oriented programming (COOP) there is a strong need for a formalism to describe concurrency. Such a formalism is ooered by Petri nets, which however lack thorough modularisation techniques for coping with models for large systems. An appropriate combination of COOP and Petri nets is required in order to proot from the strength of both methods. This paper gives ...