Sialic acid, an acetylated derivative of neuraminic acid, is reported to be a marker of micro- and macrovascular complications in diabetic subjects. The purpose of this study was to investigate the association of serum sialic acid and diabetic retinopathy. Serum sialic acid levels were measured in healthy non-diabetic control subjects, Type 2 diabetic patients without retinopathy (No DR), Type ...

The sialic acid content of erythrocytes from healthy individuals of different blood types and of patients with known hematological disorders has been determined. The sialic acid was completely released enzymatically with sialidase and quantitated by the thiobarbituric acid method. The sialic acid content of erythrocytes was constant irrespective of ABO blood type, or anticoagulant used; viz, 0....

Evading the reticuloendothelial system (RES) remains a critical challenge in the development of efficient delivery and diagnostic systems for cancer. Sialic acid (N-acetylneuraminic acid, Neu5Ac) is recognized as a "self" marker by major serum protein complement factor H and shows reduced interaction with the innate immune system via sialic acid-binding immunoglobulin-like lectin (Siglec), whic...

In recent years, the biological functions of human milk oligosaccharides and potential toxic effects red meat on health have attracted considerable attention. Sialic acid is an important carbohydrate in meat, corresponding to sialylated N-glycolylneuraminic (NeuGc, one type sialic acid). Herein, we reviewed metabolic fate dietary body their gut oral microbes. summary, NeuAc monomer directly exc...

Active inclusion bodies of polyphosphate kinase 3 and cytidine 5'-monophosphate kinase were combined with whole cells that co-express sialic acid aldolase and CMP-sialic acid synthetase. The biocatalytic mixture was used for the synthesis of CMP-sialic acid, which was then converted to 3'-sialyllactose by whole cells.

Focusing on the high dispersion of stable isotope ratios (δ13C, δ15N, δ18O, δ2H) in edible bird's nest (EBN), a robust method was developed to simultaneously discriminate and quantify three types substances (sialic acid, egg white food gums) added separately into EBN. Results showed that by establishing data processing formula improve cohesion samples' ratios, discriminant achieved with an accu...

Total serum sialic acid (TSA), total proteins (TP) and TSA/TP ratio (as tumor markers) have been estimated in 108 cancer patients, 30 pathological controls and 50 normal healthy controls. Data analysis indicated a significant increase (p< 0.001) in the TSA and TSA/TP ratio in cancer patients (98.41 ± 13.5 mg/dl and 15.31 ± 2.57 mg/gm) as compared to pathological controls (77.57 ± 21.09 mg/dl an...

Mucus secreted by colorectal cancer differs in three respects from that produced normally: an overall reduction, a loss of O-acetyl substituents in sialic acid, and an increase in neutral mucin. Similar changes have been reported in apparently normal mucosa bordering colorectal cancer. "Normal" left sided colorectal mucosa from 32 patients with rectal cancer was studied. Each case was matched b...

A defective efflux of free sialic acid from the lysosomal compartment has been found in the clinically heterogeneous group of sialic acid storage disorders. Using radiolabeled sialic acid (NeuAc) as a substrate, we have recently detected and characterized a proton-driven carrier for sialic acid in the lysosomal membrane from rat liver. This carrier also recognizes and transports other acidic mo...