Objectives: this study was conducted to obtain safety data of ethanolic extract of tempuyung leaves (EETL) on pregnant Wistar rats. Methods: Four groups of rats were used for this study, including control group, ethanolic extract of tempuyung leaves (EETL) at doses of 100 mg.kg, 400 mg.kg and 1000 mg.kg, in which each group consisted of ten pregnant rats. Extracts were administered once daily s...

Maternal alcohol consumption during pregnancy can produce teratogenic effects and has a detrimental effect on the development of the fetus. In this study, the dose-dependent effect of maternal alcohol administration on the expression of nitric oxide synthase (NOS) in the hippocampus of the offspring rats was investigated. From the present result, it was shown that expression of NOS is decreased...

A case is reported of a baby born with congenital abnormalities due to maternal ingestion of warfarin during pregnancy. Warfarin is known to be teratogenic, producing characteristic abnormalities, namely a hypoplastic nose, stippled epiphyses, and skeletal abnormalities. A variety of ocular abnormalities have been reported. Ophthalmologists should seek a history of maternal warfarin ingestion w...

We developed and optimized a screening procedure, in which zebrafish embryos were explored as a model for the evaluation of the specific embryotoxic and teratogenic potential of chemicals. A selection of known positive (retinoic acid, valproic acid, caffeine, lithium chloride) and negative (glucose, saccharin) compounds for developmental toxicity were used to evaluate this method. We exposed em...

A single intraperitoneal injection of 5-bromo-2-deoxyuridine (BUDR) between days 9 and 11 and a single intramuscular injection of 5-fluorouracil (FU) between days 8 and 11 of gestation were teratogenic in hamster. The malformation frequencies were related to the dose and time of BUDR and FU treatment but the pattern and types of malformations and their frequencies were different. BUDR showed lo...

Teratogenic and toxicological effects of lidocaine administered during pregnancy were evaluated in the Sprague Dawley rat. High doses of lidocaine administered during specific periods of gestation were shown to produce no apparent adverse toxicological or teratogenic effects. Histological, enzymological, and physical features of the fetuses, utilizing conventional toxicological parameters, were...