PURPOSE To evaluate the morphological changes of the meibomian glands (MG) in patients with meibomian gland dysfunction (MGD) compared to normal subjects by in vivo confocal microscopy and to investigate the relation of these changes to the clinical ocular surface findings and tear functions. METHODS Twenty MGD patients and 15 normal subjects were recruited into this prospective study. Patien...

The mechanics governing the fit of a soft contact lens on the eye are examined through the development of a finite element analysis model. A linearly elastic lens is placed on a rigid eye with a lubricating viscoelastic tear layer. The mechanics of fit are described in terms of the pressure distribution through the tear layer, the contact pressure at the lens/tear interface, the tear film thick...

The optical function of the eye critically depends on the presence of an intact precorneal tear film. Abnormalities of the tear film such as those occurring in the dry eye syndrome or in otherwise irritated eyes may interfere with vision. In 30 patients with dry eyes artificial tears were found to produce statistically significant improvement of vision (p less than 0.001) while no significant c...

We report the natural history of keratoconjunctivitis sicca (KCS) in two rabbit models. The first one (full KCS model) was created by closing the lacrimal gland excretory duct, and removing the nictitating membrane and harderian gland. We created the second one (lacrimal gland duct only [LGDO]-KCS model) by closing the lacrimal gland excretory duct. Although tear film osmolarity was abnormally ...

The hydrophobic surfactant proteins B (SP-B) and C (SP-C) are tightly bound to phospholipids. These proteins play important roles in maintaining the surface tension-lowering properties of pulmonary surfactant. Surfactant protein A (SP-A) and D (SP-D) are extremely hydrophilic and are thought to have a role in recycling surfactant and especially in improving host defense in the lung. Moreover, S...

Both the distribution of tear fluid over the conjunctiva and any injury to the conjunctival epithelium can be made visible by instilling a fluorescent solution into the eye and observing with an appropriate combination of excitation and barrier filters. Sulphorhodamine B, which has an orange fluorescence that can be separated from the green natural fluorescence of the ocular tissues, gives a gr...

The concentration of ions, or osmolarity, in the tear film is a key variable in understanding dry eye symptoms and disease. In this manuscript, we derive a mathematical model that couples osmolarity (treated as a single solute) and fluid dynamics within the tear film on a 2D eye-shaped domain. The model includes the physical effects of evaporation, surface tension, viscosity, ocular surface wet...

Patients presenting to an eye care professional commonly complain of symptoms related to dry eye syndrome (DES), a multi-factorial condition causing instability of the tear film which can potentially result in ocular discomfort and reduced visual function.1 It is estimated that up to a quarter of individuals seen in an optometric clinical setting report symptoms associated with dry eyes, a stat...

We compared the relative value of the tear film breakup time, Schirmer test, lactoferrin immunologic assay and rose bengal staining in 156 patients with varying severity of symptoms characteristic of keratoconjunctivitis sicca and in 39 controls. Statistical analysis showed that in patients with minimal ocular irritation the Schirmer test in combination with the lactoferrin immunologic assay pr...

PURPOSE To describe the ocular surface disorders of 362 patients with severe active atopic dermatitis (AD) treated in the Ophthalmology Department of Kobe University Hospital and Kobe Rosai Hospital Eye Clinics during the period 1994-1996. METHODS Routine ophthalmic examinations as well as tear film break-up time (BUT) and Schirmer tests were carried out. RESULTS Lid eczema (65.7%), atopic ...