نتایج جستجو برای: tale
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TALE-SPIN, the laat major AI attempt at atory generation, approached the problem of making up atoriea primarily from the perspective of an impartial world simulator. AUTHOR ia a program (under development) which generates atoriea as a creative reaaoner in purauit of her own narrative goals. It is thus intended to aimulate an author's mind aa ahe makes up a story, rather than the world as things...
The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is strong evidence for body-site-dependent dermal programming of epidermal differentiation in which the...
Introduction This workshop brought together developmental biologists and oncologists for three intense days of discussions about the recent progress that has been made on the roles of homeodomain proteins in development, haematopoiesis and leukaemogenesis. The homeo-domain is a 61-amino-acid DNA-binding motif with specific sequence and structural characteristics (Gehring & Hiromi, 1986). Homeod...
This study delineates the use of cultural hegemony in Charles Dickens’s A Tale of Two Cities (1859) through the vantage points of Italian critic Antonio Gramsci (1891-1937) who clarifies domination of the ruling class over ruled class. Cultural hegemony is the mastery of the middle class and governing groups among the lower divisions. Antonio Gramsci declares that the only means of keeping cult...
Spinal muscular atrophy (SMA) is a primary genetic cause of infant mortality due to mutations in the Survival Motor Neuron (SMN) 1 gene. No cure is available. Antisense oligonucleotides (ASOs) aimed at increasing SMN levels from the paralogous SMN2 gene represent a possible therapeutic strategy. Here, we tested in SMA human induced pluripotent stem cells (iPSCs) and iPSC-differentiated motor ne...
Biological computing circuits can enhance our ability to control cellular functions and have potential applications in tissue engineering and medical treatments. Transcriptional activator-like effectors (TALEs) represent attractive components of synthetic gene regulatory circuits, as they can be designed de novo to target a given DNA sequence. We here demonstrate that TALEs can perform Boolean ...
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