نتایج جستجو برای: soluble leptin receptor
تعداد نتایج: 677692 فیلتر نتایج به سال:
leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action. the reducing effect of α2-adrenoceptors inhibition on body weight and appetite and also enhancing effects on lipolysis, sympathetic activation and plasma insulin levels in animals have been reported. we studied the effect of yohimbine treatment (2 mg...
Leptin has been proposed to modulate cardiac electrical properties via β-adrenergic receptor activation. The presence of leptin receptors and adipocytes in myocardium raised a question as to whether leptin can directly modulate cardiac electrical properties such as heart rate and QT interval via its receptor. In this work, the role of local direct actions of leptin on heart rate and ventricular...
OBJECTIVE To explore the determinants of the tumor necrosis factor alpha (TNFalpha) system and their relationship with plasma leptin levels. METHODS We studied a cohort of 157 diabetic and non-diabetic females with a wide range of adiposity distributed into five groups: control--body mass index (BMI) between 19 and 27 kg/m(2) (n=24); obese--BMI between 27 and 40 kg/m(2) (n=63); obese type 2 d...
Insulin and leptin have overlapping effects in the control of energy homeostasis, but the molecular basis of this synergism is unknown. Insulin signals through a receptor tyrosine kinase that phosphorylates and activates the docking proteins IRSs (insulin receptor substrates), whereas the leptin receptor and its associated protein tyrosine kinase JAK2 (Janus kinase 2) mediate phosphorylation an...
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