In vitro testing of drugs with excised human skin is a valuable prerequisite for clinical studies. However, the analysis of excised human skin presents several obstacles. Ongoing drug diffusion, microbial growth and changes in hydration state influence the results of drug penetration studies. In this work, we evaluate freeze-drying as a preserving preparation method for skin samples to overcome...

Vacuum freeze-drying has been considered the best dehydration process for thermolabile products because it reduces nutritional and sensorial degradation. As water is removed from a pre-frozen product, a porous structure is formed, which results in a dehydrated product that has better properties when rehydrated.1 This technique springs up rapidly along with the development of refrigeration, vacu...

1 Department of Pharmaceutics, Seven Hills College of Pharmacy, Tirupathi, AP, India. 2 Faculty, Department of Pharmaceutics, OMER EL MUKHTAR University, Al-Beida, Libiya 3 Department of Pharmaceutical Chemistry, Shankarlingam Bhuvaneswari College of Pharmacy, Sivakasi, TN,India 4 Principal, Seven Hills College of Pharmacy, Tirupathi, AP, India 5 Research Director, Seven Hills College of Pharma...

Publishing in economics proceeds much more slowly on average than the natural sciences, and other social sciences finance. It is even relatively slower at extremes. We demonstrate that of lag, especially extremes, arises from authors' dilatory behavior revising their work. The marginal product an additional round re-submission top journals productive subsequent citations; but conditional re-sub...

A bstract We consider models of decaying spin-1 dark matter whose dominant coupling to the standard model sector is through a dark-Higgs Yukawa portal connecting TeV-scale vector-like lepton (right-handed) electron. Below electron-positron threshold, has very slow, loop-suppressed decays photons and (electron) neutrinos, stable on cosmological time-scale for sufficiently small gauge values. Its...

We compared hepatitis B virus (HBV) surface antigen, anti-hepatitis C virus (HCV) antibody, and HCV RNA quantification in frozen and freeze-dried serum samples to assess the usefulness of freeze-dried sera for detection of HBV and HCV. The results indicated that freeze-dried sera as well as frozen sera can be useful for serological and molecular biological analyses of HBV and HCV.

The Sichuan-Tibet grid connection project is a national key project implemented in accordance with the developmental needs of Tibet and the living requirements of 700 thousand local residents. It is the first grid project with special high voltage that passes through eastern margin of the Tibetan Plateau. The ground deformation due to widely distributed landslides and debris flow in this area i...

Modal parameters can reflect the dynamic characteristics of structure and be used to control vibration. To identify operational modal linear slow-time-varying structures only from non-stationary vibration response signals, a method based on moving window locality preserving projections (MWLPP) algorithm is proposed. Based theory “time freeze”, selects fixed length takes displacement signal in e...

Erythrocytes collected from 1-day-old chicks were stabilized by fixation with formaldehyde and by freeze-drying after treatment with carbon monoxide. Suspensions of freeze-dried erythrocytes in distilled water or physiological saline had a homogeneous bright reddish-purple color. Freeze-dried erythrocytes were compared with fresh erythrocytes for hemagglutination and hemagglutination-inhibition...