Here we report that ILK localizes in the mouse primary cilium, a sensory organelle required for signalling by the Hedgehog (Hh) pathway. Genetic or pharmacological inhibition of ILK blocks ciliary accumulation of the Hh pathway effector smoothened (Smo) and suppresses the induction of Gli transcription factor mRNAs by SHh. Conditional deletion of ILK or Smo also inhibits SHh-driven activation o...

Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates severa...

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extend...

Abscisic acid (ABA) is a vital hormone that confers abiotic stress tolerance in plants. The identification of PYR/PYL/RCAR proteins as bona fide ABA recep‐ tors and the subsequent elucidation of the structural mechanisms of the core ABA signalling pathway in recent years has provided new and powerful in‐ sights in targeting ABA signalling to enhance abiotic stress tolerance in agri‐ culture. Th...

Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor κB (NF-κB) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling t...

Jasmonates, derivatives of jasmonic acid, are lipid-derived oxylipins with cyclopentanone ring, produced as a result dioxygenation mediated by lipoxygenases. The biosynthesis acid is catalysed series different enzymes, starting from lipoxygenase, allene oxide synthase, cyclase and 12-oxophytodienoic reductase to the final three rounds β-oxidation. Consequently, few metabolites known jasmonates ...

Determination of cell signalling behaviour is crucial for understanding the physiological response to a specific stimulus or drug treatment. Current approaches for large-scale data analysis do not effectively incorporate critical topological information provided by the signalling network. We herein describe a novel model- and data-driven hybrid approach, or signal transduction score flow algori...

Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer. We show here that the JNK MAP kinase pathway and one of its most important substrates, the AP-1 transcription factor c-Jun, modulates Wnt signalling strength in the intestine. Transgenic gut-specific augmentation of JNK signalling stimulated progenitor cell proliferation and migration, resulting in inc...

Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus flavonoid with remarkable anti-inflammatory activity, but the mechanisms underlying its inhibition of LPS/TLR4 signalling are less clear. This study investigated the molecular targets and ...