Coumarins are a very common type of secondary plant metabolites with a broad spectrum of biological activities. Psoralidin is a naturally occurring furanocoumarin isolated from Psoralea corylifolia possessing anticancer and chemopreventive properties. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in cancer cells with no toxicity toward normal tissues. Endoge...

Introduction: It has been shown that three new synthetic coumarins-3-carboxamides including 3-fluorobenzilchloride, 4-fluorobenzilchloride and 2-hidroxy-3 metoxybenzaldehyde, have acetylcholinesterase inhibitory activity. This study was performed to estimate ameliorating effect of these new coumarin-3-carboxamides on memory impairments induced by scopolamine (1 mg/kg, induced prolongation) in m...

The Front Cover shows the most active molecule of a series nitrate coumarins, coumarin-7-yl-methyl nitrate, that “magically” releases nitric oxide into bloodstream, leading to vasodilatory effect. Synthesized nitrate−coumarins show potent vasodilator activity on isolated rat aortic rings deprived endothelium, with higher effect those pre-contracted phenylephrine than potassium chloride. This su...