Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sauflon 85 lenses. The aqueous drug levels were biologically estimated at various time intervals. Soft contact lenses provided significantly higher drug penetration than subconjunctival therapy. Both mo...

The following table gives an analysis of two hundred consecutive cases of cataract extraction since Ma}', 1896. I liave before me notes of every case. The operations have been performed in about equal numbers by Mr. Arthur Neve and myself. But during the past four months, in the absence of Mr. Arthur Neve, my friend, Mr. W. F. Adams, has been my colleague. (1) Variety.?Senile 189; soft 6; glauc...

Histological changes were studied in 34 senile cataractous lenses removed surgically from patients aged 50 to 78 years. Sixty-eight percent had nuclear sclerosis, 44% swollen cells and morgagnian globular changes, 23% calcium deposition, 15% migration of epithelial cells beneath posterior capsule and villous projection in posterior in 7%. Several cases had more than one histological abnormality...

P.inna, a Hindoo female, a^e;l between GO and 70 years, was admitted into the Srinagar Dispensary on the 18th of November 1879. For the last five years she had completely lost the use of her eyes owing to senile cataract. She was very weak. In order to improve her health I gave her nourishing food and ferruginous tonics till the 23rd idem, when she was laid on the table for operation. The lens ...

METHODS: Patients with senile monocular cataract were randomly assigned to receive either a blue light-filtering aspheric IOL (Aspira-aAY group), its clear aspheric counterpart (Aspira-aA group) or the clear spherical model (AS group). The primary outcome measures were visual acuity for distance, intermediate (1 m), near (40 cm), contrast sensitivity under photopic (85 cd2) and mesopic (3 cd2) ...

The aim of this study was to investigate the effects of phacoemulsification with intraocular lens (IOL) implantation on intraocular pressure (IOP) and anterior chamber depth (ACD) in patients with cataract or cataract associated with primary angle closure (PAC). A total of 361 patients (481 affected eyes) with senile cataract (cataract group) and 44 patients (52 affected eyes) with cataract ass...

UV irradiation has the potential to induce the development of lens opacities. This has been demonstrated since long with animal experiments. Unfortunately these animal cataracts did not explain or elucidate the epidemiological observation that the frequency of human cataracts--such as the so called senile cataract--is remarkably higher in regions with increased cosmic UV irradiation or in the p...

Age-related macular degeneration (AMD) and cataract are common age-related diseases in humans. Previously we showed that senescence-accelerated OXYS rats develop retinopathy and cataract, which are comparable to human AMD and senile cataract. Here we focused on the identification of quantitative trait loci (QTLs), which affect early-onset cataract and retinopathy in OXYS rats, using F2 hybrids ...

The tissue localization and subcellular distribution of drug-metabolizing enzymes in the eye are described. With the use of inbred strains of mice, the [Ah] complex is shown to be an important experimental system for probing genetic differences in drug metabolism and related drug toxicities. Although the genetic system described in detail here involves mice, there is ample evidence that the sam...