Escitalopram (escitalopram oxalate; Cipralex(®), Lexapro(®)) is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of major depressive disorder (MDD) and anxiety disorder. This drug exerts a highly selective, potent, and dose-dependent inhibitory effect on the human serotonin transport. By inhibiting the reuptake of serotonin into presynaptic nerve endings, this drug enhance...

ackground: There is growing evidence that individual differences among depressed patients on electrophysiologic (EEG), neuroim nd neurocognitive measures are predictive of therapeutic response to antidepressant drugs. This study replicates prior find retreatment differences between selective serotonin reuptake inhibitor (SSRI) responders and nonresponders in EEG alpha po symmetry and examines w...

We report a case of a patient with severe hyperacusis, photophobia, and skin hypersensitivity. The patient was initially treated with sound therapy and medical therapy for 4 months and successfully with a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy which improved her mood and the tolerance for sounds and light.

In this issue of Neuron, Richardson-Jones et al. report on a novel genetic approach to conditionally and specifically dampen the function of the 5-HT(1A) autoreceptor in mice to study its role on the 5-HT system and on the antidepressant-like effect of the selective serotonin reuptake inhibitor (SSRI) fluoxetine.

Three patients with premenstrual dysphoric disorder (PMDD) and recurrent vulvovaginal candidiasis (VVC) underwent sertraline therapy (Tresleen, a selective serotonin-reuptake inhibitor; Pfizer) for PMDD. During sertraline intervention, patients had no recurrent episodes of acute VVC. Antifungal activity was observed for sertraline against various isolates of Candida species.

Submit Manuscript | http://medcraveonline.com Abbreviations: FXS: Fragile X syndrome; PVET: Passive-Viewing Eye Tracking Task; MSEL: Mullen Scales of Early Learning; PLS: Preschool Language Scale; FMR1: Fragile X Mental Retardation 1; FMRP: FMR1 Protein; SSRI: Selective Serotonin Reuptake Inhibitor; ASD: Autism Spectrum Disorder; CA: Chronological Age; MA: Mental Age; CDI: MacArthur-Bates Commu...

Prompted by the suggested importance of respiration for the pathophysiology of panic disorder, we studied the influence of serotonin reuptake inhibitors (SRIs) as well as other serotonin-modulating compounds on respiration in freely moving rats. The effect on respiration after acute administration of compounds enhancing synaptic levels of serotonin, that is, the serotonin reuptake inhibitors pa...

For a long time, there has been a misconception that all antidepressant drugs have proconvulsant effects. Yet, antidepressants of the selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) families have been not only shown to be safe when used in patients with epilepsy (PWE) but have been found to display antiepileptic properties in animal models of...