Sulfa drugs are well-known antibacterial agents containing N-substituted sulfonamide group on para position of aniline ring (NH2RSO2NHR'). In this study 2,4-dichloro-1,3,5-triazine derivatives of sulfa drugs, sulfamerazine (1b), sulfaquinoxaline (2b), sulfadiazine (3b), sulfadimidine (4b), and sulfachloropyrazine (5b) (1a-5a) were synthesized and characterized. Their carbonic anhydrase inhibiti...

A series of 1,3,5-triazine derivatives that contain aniline, 4-hydroxycoumarin and 7-hydroxy-4-methylcoumarin and different piperazines and piperidines as substituents on the carbon atoms of the triazine ring has been synthesized by a simple and efficient synthetic protocol. Comparative studies were performed on above compounds, which were synthesized with conventional and microwave heating met...

Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions. In a final alkylation step a further substituent may be introduced. The synthetic strategy allows broad structural variation of this new drug-like heterobicyclic scaffold. In add...

Two types of simazine-degrading microorganisms were isolated from soil samples where the herbicide had been spread with the enrichment culture using simazine as the sole carbon and nitrogen source. A fungal strain, DS6F, identified as Penicillium steckii, is the first simazine-degrading fungus ever reported. Ž Simazine was gradually degraded by P. steckii DS6F in the mineral medium containing s...

The synthesis of some new 1,3,4-oxadiazole derivatives and 1,2,4-triazine-5-one has been described. IR, H NMR and mass spectral data support the structures of newly synthesized compounds. All the compounds have been tested in vivo for their anti-inflammatory activity by carrageenin-induced rat paw edema method. The compounds, which show good antiinflammatory activity, have been screened for the...

Nine mycorrhizal fungi and free-living saprophytic microorganisms were tested for their ability to degrade two chlorinated aromatic herbicides at two herbicide concentrations and three nitrogen concentrations. Radiolabelled 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-chloro-4-ethylamino-6-isopropylamino-s-triazine (atrazine) were used as substrates at concentrations of 1 and 4 mM. After 8 week...

Eleven compounds have been synthesized in a series of [1, 3, 5] triazine analogues which, in addition to 4-amino benzonitrile, contain 8-hydroxy quinoline and different piperazines as well as piperidine substituents on the C-6 position of s-triazine ring. The title compounds were then evaluated for their in vitro microbial activity against 2 gram –Ve bacteria (E.coli, P. aeruginosa), 2 gram +Ve...

Photopolymerization has attracted great interest because of its mild reaction conditions, spatiotemporal controllability, cost efficiency, and fast speed. However, with the raising environmental awareness increasing attention to life health, leachability photoinitiators become a growing concern. In this research, methacrylate functionalized triazine-based polymerizable visible light photoinitia...

A facile and convenient synthesis of new heterocyclic compounds containing a sulfamoyl moiety suitable for use as antimicrobial agents was reported. The precursor 3-oxo-3-phenyl-N-(4-sulfamoylphenyl)propionamide was coupled smoothly with arenediazonium salt producing hydrazones which reacted with malononitrile or triethylorthoformate affording pyridazine and triazine derivatives, respectively. ...