BACKGROUND The efficacy of local anesthetic wound infiltration for the treatment of acute and chronic postoperative pain is controversial and there are no detailed studies. The primary objective of this study was to evaluate the influence of ropivacaine wound infiltration on chronic pain after breast surgery. METHODS In this prospective, randomized, double-blind, parallel-group, placebo-contr...

BACKGROUND The main determinant of continuous peripheral nerve block effects--local anesthetic concentration and volume or simply total drug dose--remains unknown. METHODS We compared two different concentrations and basal rates of ropivacaine--but at equivalent total doses--for continuous posterior lumbar plexus blocks after hip arthroplasty. Preoperatively, a psoas compartment perineural ca...

Background And Aims: Brachial plexus block is the cornerstone of regional anaesthesia practice. Various adjuncts have been used as adjuvants to ropivacaine in the past. This study was done to see the effect on duration of analgesia using dexmedetomidine as adjuvant to ropivacaine 0.5% in supraclavicular brachial plexus block (SBPB). Method: A total of eighty patients undergoing elective upper l...

BACKGROUND Retrospective analysis of patients undergoing cancer surgery suggests the use of regional anesthesia may reduce cancer recurrence and improve survival. Amide-linked local anesthetics have antiinflammatory properties, although the mechanism of action in this regard is unclear. As inflammatory processes involving Src tyrosine protein kinase and intercellular adhesion molecule-1 are imp...

BACKGROUND It remains unclear whether local anesthetic concentration or total drug dose is the primary determinant of continuous peripheral nerve block effects. The only previous investigation, involving continuous popliteal-sciatic nerve blocks, specifically addressing this issue reported that insensate limbs were far more common with higher volumes of relatively dilute ropivacaine compared wi...

A rectus sheath block can provide postoperative analgesia for midline incisions. However, information regarding the pharmacokinetics of local anesthetics used in this block is lacking. In this study, we detail the time course of ropivacaine concentrations after this block. Thirty-nine patients undergoing elective lower abdominal surgery were assigned to 3 groups receiving rectus sheath block wi...

BACKGROUND Pregnancy is associated with a higher spread of subarachnoid anaesthesia and increased pain threshold. The study was designed to assess the spread of subarachnoid block and the intra- and postoperative analgesic requirements in pregnant vs non-pregnant women. METHODS We assessed the level of subarachnoid anaesthesia after 1.8 ml of hyperbaric lidocaine 5% and the postoperative anal...

BACKGROUND Thoracic epidural anesthesia (TEA) exacerbates hypotension due to peripheral vasodilator effects following the use of general anesthetics. This study aimed to compare the hemodynamic changes caused by three different concentrations of epidural ropivacaine and to evaluate the performance of the stroke-volume variation (SVV) and central venous pressure (CVP) during TEA with general ane...

conclusions instillation of ropivacaine 0.2% (30 ml) within tubeless pcnl surgery does not have a significant effect on postoperative pain relief and improvement of pef within 6 hours after the operation. results we found no difference in the mean pain severity score between the case and control groups 4 hours (p = 0.332) and 6 hours (p = 0.830) after the operation. the mean pef at baseline was...

Background: Use of adjuncts to local anaesthetics improves the quality subarachnoid block (SAB). We compared intrathecal clonidine-ropivacaine combination and fentanyl-ropivacaine for duration sensory motor associated side effects.
 Subjects methods: 80 patients undergoing elective vaginal hysterectomy under SAB were enrolled this hospital-based, prospective, randomized, double-blind study...