Loss of retinal ganglion cells (RGCs) occurs in retinal degenerative diseases, such as glaucoma, age-related macular degeneration, diabetic retinopathy, central retinal artery occlusion and ischemic central retinal vein thrombosis in adults and in retinopathy of prematurity in infants. A critical role of hypoxia, which underlies most of the above disorders, has been reported in causing RGC deat...

Puroose: Proliferative diabetic retinopathy is assumed to develop because vasogenic factors are released from retinal areas that are ischaemic and hypoxic secondary to occlusion of the retinal vascular bed. It has been propclsed that vascular occlusion in diabetic retinopethy may be due to the deposition of periodic acid Schiff positive glycoprotein compounds in the retinal vascular walls. but ...

For years, diabetic retinopathy has been defined based on vascular lesions, and neural abnormalities were not regarded as important. This review summarizes evidence that the neural retina has important effects on the retinal vasculature under normal conditions, and the interaction between the retinal neuroglial cells and vascular function is altered in diabetes. Importantly, new evidence raises...

ocular involvement in lymphoma is a relatively rare condition that can result from a primary intraocular lymphoma or an intraocular manifestation of systemic lymphoma. lymphoma manifestations frequently masquerade as other more benign intraocular conditions including allergic or infectious conjunctivitis, uveitis, multiple evanescent white dot syndrome, acute retinal necrosis, or herpetic retin...

Cutis marmorata telangiectatica congenita is a well-characterized cutaneous vascular disorder with variable and rare ocular involvement. It has been reported in association with glaucoma, bilateral congenital retinal detachments, bilateral tractional retinal detachments secondary to proliferative vitreoretinopathy, and retinoblastoma. This case demonstrates novel findings of bilateral periphera...

Puroose: Proliferative diabetic retinopathy is assumed to develop because vasogenic factors are released from retinal areas that are ischaemic and hypoxic secondary to occlusion of the retinal vascular bed. It has been propclsed that vascular occlusion in diabetic retinopethy may be due to the deposition of periodic acid Schiff positive glycoprotein compounds in the retinal vascular walls. but ...

Puroose: Proliferative diabetic retinopathy is assumed to develop because vasogenic factors are released from retinal areas that are ischaemic and hypoxic secondary to occlusion of the retinal vascular bed. It has been propclsed that vascular occlusion in diabetic retinopethy may be due to the deposition of periodic acid Schiff positive glycoprotein compounds in the retinal vascular walls. but ...

Retinal vascular disorders are a leading cause ofhuman visual impairment. It is only within the past decade, however, that methodologies such as fluorescein angiography (Novotny and Alvis, I96I) and retinal digestion (Kuwabara and Cogan, I960) have been developed which permit us accurately to delineate the various features of retinal vascular disease. We must remember that retinal vascular resp...

This paper describes the ophthalmological features of 150 patients with idiopathic retinal vasculitis, 67 of whom had isolated retinal vasculitis (RV) and 83 had RV associated with systemic inflammatory disease (RV + SID). The diagnosis of retinal vasculitis was made by ophthalmoscopy and fluorescein angiography, and patients with any identifiable cause (infection, ischaemia, or malignancy) wer...

Diabetic retinopathy is a leading cause of adult vision loss and blindness. Much of the retinal damage that characterizes the disease results from retinal vascular leakage and nonperfusion. This study shows that diabetic retinal vascular leakage and nonperfusion are temporally and spatially associated with retinal leukocyte stasis (leukostasis) in the rat model of streptozotocin-induced diabete...