This article argues that the fundamental typological distinction pertaining to reduplication is that between phonological duplication and morphological doubling (the Dual Theory of reduplication). Phonological duplication, which occurs for a phonological purpose such as providing an onset or nucleus for a syllable or filling in the featural content of an otherwise unspecified timing unit in the...

Centrosome overduplication promotes mitotic abnormalities, invasion and tumorigenesis. Cells regulate the number of centrosomes by limiting centriole duplication to once per cell cycle. The orthogonal orientation between a mother and a daughter centriole, established at the time of centriole duplication, is thought to block further duplication of the mother centriole. Loss of orthogonal orienta...

PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole. Centriole engagement is known to block the reduplication of mother centrioles, but the molecular identity responsible for the block remains unclear. Here, we show that the centriolar cartwhe...

Centrosomes, each containing a pair of centrioles, organize microtubules in animal cells, particularly during mitosis. DNA and centrosomes are normally duplicated once before cell division to maintain optimal genome integrity. We report a new role for the Orc1 protein, a subunit of the origin recognition complex (ORC) that is a key component of the DNA replication licensing machinery, in contro...

Chinese character structure has often been described as representing a kind of grammar, but the notion of character grammar has hardly been explored. Patterns in character element reduplication are particularly grammar-like, displaying discrete combinatoriality, binarity, phonology-like final prominence, and potentially the need for symbolic rules (X→XX). To test knowledge of these patterns, Ch...

This paper describes a model for the automated morphological analysis of Bahasa Malaysia (the Malay language) via the ATEF system, a component of the mechanical translation system known as ARIANE, which was developed by G.E.T.A. at Grenoble. This model serves two purposes, that is, to test the capability of handling Bahasa Malaysia morphological analysis using ATEF and also to provide a first w...

The yeast Mps1p protein kinase acts in centrosome duplication and the spindle assembly checkpoint. We demonstrate here that a mouse Mps1p ortholog (esk, which we designate mMps1p) regulates centrosome duplication. Endogenous mMps1p and overexpressed GFP-mMps1p localize to centrosomes and kinetochores in mouse cells. Overexpression of GFP-mMps1p causes reduplication of centrosomes during S phase...

This paper presents a computational investigation of a range of morphological operations. These operations are first represented as morphological maps, or functions that take a stem as input and return an output with the operation applied (e.g., the ing-suffixation map takes the input ‘dôINk’ and returns ‘dôINk+IN’). Given such representations, each operation can be classified in terms of the c...

We formally and empirically examine the phonological relation immediate precedence, its properties, and further relations that can be derived from it. When each occurrence of a phonological segment in a nonlinear multiprecedence structure is reconcatenated into a linear sequence of copies, reduplication results (Raimy 2000a). A number of consequences arise in the representation of affixes, in m...