نتایج جستجو برای: rebound activity
تعداد نتایج: 1139383 فیلتر نتایج به سال:
Abstract In general, the mechanisms that maintain activity of neural systems after a triggering stimulus has been removed are not well understood. Different involving at cellular and network levels have proposed. this work, based on analysis computational model spiking network, it is proposed spike occurs neuron inhibited (the rebound spike) can be used to sustain in recurrent inhibitory circui...
Price policies are one of the most permissive policies in Iranian economic for controlling energy carrier's consumption. In addition, the non-price policies such as energy efficiency improvement are effective for controlling energy carrier's consumption. This paper assesses the economic impacts of energy efficiency improvement (in gasoline, gasoil and electric) as a non-price policy. For the pu...
Human immunodeficiency virus type 1 (HIV-1) fuses with cells after sequential interactions between its envelope glycoproteins, CD4 and a coreceptor, usually CC chemokine receptor 5 (CCR5) or CXC receptor 4 (CXCR4). CMPD 167 is a CCR5-specific small molecule with potent antiviral activity in vitro. We show that CMPD 167 caused a rapid and substantial (4-200-fold) decrease in plasma viremia in si...
INTRODUCTION Natalizumab (NTZ) discontinuation can be followed by multiple sclerosis (MS) disease reactivation. Currently no disease-modifying drug (DMD) has been shown to be able to abolish disease reactivation. The aims of the current study were: (1) to determine the frequency of MS reactivation after NTZ discontinuation; (2) to evaluate predictors of reactivation risk, and (3) to compare the...
BACKGROUND The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passive administration of VRC01, a bNAb targeting the HIV CD4-binding site, can safely prevent or delay plasma viral rebound after the discont...
Despite considerable evidence that neural activity in monkeys reflects various aspects of face perception, relatively little is known about monkeys' face processing abilities. Two characteristics of face processing observed in humans are a subordinate-level entry point, here, the default recognition of faces at the subordinate, rather than basic, level of categorization, and holistic effects, i...
Central neural networks operate continuously throughout life to control respiration, yet mechanisms regulating ventilatory frequency are poorly understood. Inspiration is generated by the pre-Bötzinger complex of the ventrolateral medulla, where it is thought that excitation increases inspiratory frequency and inhibition causes apnea. To test this model, we used an in vitro optogenetic approach...
The medial septum diagonal band area (MS/DB) projects to the hippocampus through the fornix/fimbria pathway and is implicated in generating hippocampal theta oscillations. The hippocampus also projects back to the MS/DB, but very little is known functionally about this input. Here, we investigated the physiological role of hippocamposeptal feedback to the MS/DB in a complete in vitro septohippo...
The developmental increase in the strength of inhibitory synaptic circuits defines the time window of the critical period for plasticity in sensory cortices. Conceptually, plasticity of inhibitory synapses is an attractive mechanism to allow for homeostatic adaptation to the sensory environment. However, a brief duration of visual deprivation that causes maximal change in excitatory synapses pr...
Wang and Brown8 were the first to describe the terminal rebound and, except for the fact that it is seen after stimulation of purely muscular nerves, the present experiments confirm theirs in essence. It is agreed that afferent C fibers must be active for the effect to appear. Another condition seems to be that the C fiber reflex must fall during the course of the A fiber reflex; otherwise, the...
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