Introduction: Multiple sclerosis (MS) is a lifelong disease of the brain and spinal cord. Fingolimod is an oral drug which modulates the S1P receptor and is used for relapsing remitting form of MS and can causes rebound activity if it is ceased even in a short period of washout time.   Case Report: Here, we introduce a young girl, a known case of MS, who developed revers...

Rebound burst activity can be generated in neurons in the subthalamic nucleus (STN) by strong GABAergic inhibitory inputs from the globus pallidus externa (GPe) that is reciprocally connected with the STN. It has been proposed that the rebound burst activity in STN neurons is a key event for generating synchronized rhythmic burst activity in the GPe-STN loop, which may be relevant to the restin...

The postinhibitory rebound excitation is an intrinsic property of thalamic and cortical neurons that is implicated in a variety of normal and abnormal operations of neuronal networks, such as slow or fast brain rhythms during different states of vigilance as well as seizures. We used dual simultaneous intracellular recordings of thalamocortical neurons from the ventrolateral nucleus and neurons...

A serendipitous observation led to this study of V1 activity rebounds, which occur well after stimulus offset, and their relationship to visual aftereffects. We found that when a stimulus bar and background were simultaneously turned off, there was strong delayed rebounding activity (distinct from any off response). The neural rebound started 350-500 ms after stimulus offset, and its magnitude ...

The cerebellum refines the accuracy and timing of motor performance. How it encodes information to perform these functions is a major topic of interest. We performed whole cell and extracellular recordings of Purkinje cells (PCs) and cerebellar nuclei neurons (CNs) in vivo, while activating PCs with light in transgenic mice. We show for the first time that graded activation of PCs translates in...

This article presents a model using cellular resonance and rebound properties to model grid cells in medial entorhinal cortex. The model simulates the intrinsic resonance properties of single layer II stellate cells with different frequencies due to the hyperpolarization activated cation current (h current). The stellate cells generate rebound spikes after a delay interval that differs for neur...

The medial entorhinal cortex is the gateway between the cortex and hippocampus, and plays a critical role in spatial coding as represented by grid cell activity. In the medial entorhinal cortex, inhibitory circuits are robust, and the presence of the h-current leads to rebound potentials and rebound spiking in in vitro experiments. It has been hypothesized that these properties, combined with n...

BACKGROUND To compare the intraocular pressure readings obtained with the iCare rebound tonometer and the 7CR non-contact tonometer with those measured by Goldmann applanation tonometry in treated glaucoma patients. DESIGN A prospective, cross-sectional study was conducted in a private tertiary glaucoma clinic. PARTICIPANTS OR SAMPLES One hundred nine (54 males : 55 females) patients includ...