Radiation therapy is a staple cancer treatment approach that has significantly improved local disease control and the overall survival of cancer patients. However, its efficacy is still limited by the development of radiation resistance and the presence of residual disease after therapy that leads to cancer recurrence. Radiation impedes cancer cell growth by inducing cytotoxicity, mainly caused...

Introduction: Computed tomography (CT) consists of 11% of all imaging methods, but accounts for approximately 67% of radiation exposure due to diagnostic cases. More than one-third of all CT scans are done in the head and neck area. The thyroid gland is irradiated during CT head and neck. According to studies, this gland has the highest levels of radiation-induced cancer, and i...

Objective(s): Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis pathway on radiosensitivity and normal tissue complications caused by the ...

background: pulmonary complications of radiation to breast are inevitable, while its incidence and severity are not clear. one of the methods to assess pulmonary complications is spirometry. the influence of radiotherapy on pulmonary function test and the factors affecting it have been assessed in this study. methods: breast cancer patients with stage ii and iii (based on tnm staging), underwen...