We have expanded the sentence in the abstract background as suggested by the reviewer, so that it now reads: “Such interventions can only have a significant impact on health and health care if they are shown to be effective when tested, are capable of being widely implemented and can be normalised into routine practice”. Abstract Summary has also been amended in line with the reviewer’s comment...

In this paper we view Pd,NP as the problem which symbolizes the attempt to understand what is and is not feasibly computable. The paper shortly reviews the history of the developments from Göde1's 1956 letter asking for the computational complexity of finding proofs of theorems, through computational complexity, the exploration of complete problems for NP and PSPACE, through the results of stru...

Near peer teaching (NPT) is becoming recognized as a valuable instrument with advantages for both students and teachers. Despite the benefits, NPT programmes are not usually embedded within university healthcare curricula and, to our knowledge, there have been few studies assessing medical students’ attitudes towards histology courses. Our study first that assess perceptions concerning value of...

This paper presents a feature point tracking algorithm using optical flow under the non-prior training active feature model (NPTAFM) framework. The proposed algorithm mainly focuses on analysis of deformable objects, and provides real-time, robust tracking. The proposed object tracking procedure can be divided into two steps: (i) optical flow-based tracking of feature points and (ii) NPT-AFM fo...

In order to diagnose allergic rhinitis (AR), skin prick tests and serum specific IgE level are the most common used methods. But there are some conditions which the results of both methods do not correlate with the clinical presentation of AR. Nasal provocation test is the method of detecting local IgE at the shock organ. There are some variations of NPT in terms of dosage, allergen administrat...

A modification of the constrained equations of motion of Kalibaeva et al. [Mol. Phys. 101, 765 (2003)] in the NPH and NPT ensembles is presented. The modified equations of motion are discretized using central-difference techniques, and the derived integrators are time reversible and conserve the invariant phase space measure. The constraint algorithm builds on the work of Toxvaerd et al. [J. Ch...

BACKGROUND Optimizing the dietary intake of older people can prevent nutritional deficiencies and diet-related diseases, thereby improving quality of life. However, there is evidence that the nutritional intake of older people living in care homes is suboptimal, with high levels of saturated fat, salt, and added sugars. The UK Food Standards Agency therefore developed nutrient- and food-based g...

Flow properties of dendrimers are studied with the aid of nonequilibrium molecular dynamics techniques. Simulations are performed in the NpT ensemble using the NpT-SLLOD algorithm [P. J. Davis and D. J. Evans, J. Chem. Phys. 100, 541 (1994)] and are compared to the results from simulations performed in the NVT ensemble reported earlier [J. T. Bosko, B. D. Todd, and R. J. Sadus, Chem. Phys. 121,...

Nested Sampling (NS) is a powerful athermal statistical mechanical sampling technique that directly calculates the partition function, and hence gives access to all thermodynamic quantities in absolute terms, including absolute free energies and absolute entropies. NS has been used predominately to compute the canonical (NVT) partition function. Although NS has recently been used to obtain the ...