Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as an inhibitor of oxidative phosphorylation. Here, we show that serine withdraw...

The structures of some Tc-biguanide complexes are predicted by molecular mechanics calculations. In addition, simulations of molecular interactions between the predicted equilibrium structures with water molecules or peptide chains are correlated with experimental data of partition coefficients and percentage of human protein binding, evaluated for the analogous 99mTc-biguanide complexes. These...

Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked withou...

The most important objectives of this presentation are to attract attention that the associations between oral anti-diabetics drugs and statin at the categories of patients with type 2 obese diabetes mellitus and dyslipidaemia, is dangerous. We know that diabetic patient’s type 2 obese needs diet and oral antidiabetics drugs (biguanide or combination between biguanide and sulfonylurea) to maint...

Although the PHMG (polyhexamethylene guanidine) and other oligomer guanidines are known as highly efficient biocides against a broad spectrum of microorganisms and eukaryotic cells, the cell protection by PHMG derivatives has been established firstly in this study. The antiviral protection was also exhibited after 15 min pretreatment of different cell cultures with low-concentration of PHMG sal...

Abstract The presented article describes the method of synthesizing new ionic liquid based on a biguanide cation and tiocyanate or benzoate anion with antimicrobial properties. structure obtained was confirmed by infrared spectroscopy. Additionally, simple producing an antibacterial textile materials PE-based film addition liquid.