A complementary approach that combines NMR measurements, analysis of X-ray and neutron powder diffraction data and advanced quantum mechanical calculations was employed to study the α-polymorph of L-polylactide. Such a strategy, which is known as NMR crystallography, to the best of our knowledge, is used here for the first time for the fine refinement of the crystal structure of a synthetic pol...

Polylactide/poly[(butylene succinate)-co-adipate] (PLA/PBSA)-organoclay composites were prepared via melt compounding in a batch mixer. The weight ratio of PLA to PBSA was kept at 70:30, while the weight fraction of the organoclay was varied from 0 to 9%. Small angle X-ray scattering patterns showed slightly better dispersion in PBSA than PLA, and there was a tendency of the silicate layers to ...

A direct, efficient, and scalable method to prepare stereocomplexed polylactide (PLA)-based nanoparticles (NPs) is achieved. By an appropriate combination of fabrication parameters, NPs with controlled shape and crystalline morphology are obtained and even pure PLA stereocomplexes (PLASC) are successfully prepared using the spray-drying technology. The formed particles of varying D- and L-LA co...

Polymeric microparticles have been used widely for sustained drug delivery. Current methods of microparticle production can be improved by making homogeneous particles in size and shape, increasing the drug loading, and controlling the initial burst release. In the current study, the hydrogel template method was used to produce homogeneous poly(lactide-co-glycolide) (PLGA) microparticles and to...

s / Journal of Controlled Release 72 (2001) 225 –309 247 Introduction Biotechnology has evolved to the point that it is possible to prepare therapeutic genes for most diseases. The use of these new medicines is hampered by the lack of a suitable carrier system that helps the DNA in reaching the target cells and in the intracellular trafficking. Cationic polymers have been proposed as vectors fo...

PURPOSE The purpose of this study was to evaluate the tensile strength of surgical synthetic absorbable sutures over a period of 14 days under simulated oral conditions. METHODS Three suture materials (polyglycolic acid [PGA], polyglactin [PG] 910, and poly (glycolide-co-є-caprolactone) [PGC]) were used in 4-0 and 5-0 gauges. 210 suture samples (35 of each material and gauge) were used. All o...

Abstract Aqueous dispersions of gold and silver nanoparticles (NPs) stabilized with sodium citrate, as well polymeric NPs based on poly(lactide- co -glycolide) (70 : 30 mol %) poly(vinyl alcohol) have been obtained. The sizes determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), analytical ultracentrifugation (AUC). It has shown that the diameter both metallic pa...

Bevacizumab (Avastin(®)) has been used by ophthalmologists in many countries as an off-label drug for the treatment of wet age-related macular degeneration (AMD). Due to its short half-life necessitating frequent intravitreal injection, a method for sustained delivery is in need. We demonstrated that bevacizumab could be released in a sustained fashion over 90 days from nano- and microspheres f...

A three-dimensional (3D) composite scaffold was prepared for enhanced cartilage tissue engineering, which was composed of a poly(ε-caprolactone) (PCL) backbone network and a poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PLGA–PEG– PLGA) thermogel surface. The composite scaffold not only possessed adequate mechanical strength similar to native osteochond...