Hepatomegaly is a common finding in primary myelofibrosis (PMF), mostly due to extramedullary hematopoiesis, as demonstrated by liver biopsies in previous studies, and high serum alkaline phosphatase (ALP) is usually the most frequent associated biochemical abnormality. In the current study, we examined the clinical, prognostic and molecular correlates of increased ALP and aspartate aminotransf...

It was suggested that endocannabinoids are metabolized by cyclooxygenase (COX)-2 in the spinal cord of rats with kaolin/λ-carrageenan-induced knee inflammation, and that this mechanism contributes to the analgesic effects of COX-2 inhibitors in this experimental model. We report the development of a specific method for the identification of endocannabinoid COX-2 metabolites, its application to ...

Positive matrix factorization (PMF) is a widely used multivariate source apportionment technique. However, PMF-derived profiles are never compared to real ones because of the absence data on chemical composition emissions. The aim this study was verify validity using diagnostic ratios (DR) method and end-member mixing analysis (EMMA). polycyclic aromatic hydrocarbons (PAHs) in particulate matte...

1. Effective size of support Let X be a discrete random variable which can take on values from a finite set X of m elements, with probabilities specified by the probability mass function (pmf) p. The support of X is a set S(p(X)) {p : p i > 0, i = 1, 2,. .. , m}. Let |S(p(X))| denote the size of the support. While pmf p = [0.5, 0.5] makes both outcomes equally likely, the following pmf q = [0.9...

Protein identification by mass spectrometry (MS) is an important technique in proteomics. By searching an MS spectrum against a given protein database, the most matched proteins are sorted using a scoring function and the top one is often considered the correctly identified protein. Peptide mass fingerprinting (PMF) is one of the major methods for protein identification using MS technology. It ...

RATIONALE Using magnetic resonance imaging (MRI), we diagnosed pneumoconiosis by identifying the content and distribution of hydrogen protons in the water molecules in different tissues and lesions. PATIENT CONCERNS 25 cases of CWP patients with progressive massive fibrosis (PMF) lesions. DIAGNOSES Patients were correctly diagnosed, with one case each of Phase I and II pneumoconiosis and 23...

Recommender system is emerging as a powerful and popular tool for online information relevant to a given user. The traditional recommendation system suffers from the cold start problem and the data sparsity problem. Many methods have been proposed to solve these problems, but few can achieve satisfactory efficiency. In this paper, we present a method which combines the trust diffusion (DiffTrus...

Respiration involves the oxidation and reduction of substrate for the redox-linked formation of a protonmotive force (PMF) across the inner membrane of mitochondria or the plasma membrane of bacteria. A mechanism for PMF generation was first suggested by Mitchell in his chemiosmotic theory. In the original formulations of the theory, Mitchell envisaged that proton translocation was driven by a ...

The correlations between progressive massive fibrosis (PMF), emphysema, and impairment of ventilation were studied in 108 dead coalminers, all of whom had suffered with complicated coalworkers' pneumoconiosis (radiological category B or C) during life. The findings indicated that both factors were contributing to impairment of ventilation in proportion to their size or extent, but these contrib...

The light reactions of photosynthesis store energy in the form of an electrochemical gradient of protons, or proton motive force (pmf), comprised of electrical (Δψ) and osmotic (ΔpH) components. Both components can drive the synthesis of ATP at the chloroplast ATP synthase, but the ΔpH component also plays a key role in regulating photosynthesis, down-regulating the efficiency of light capture ...