EPA’s research-based regulations have fostered significant strides in environmental improvement in the United States and inspired analogous endeavors around the globe. Notably, air quality has improved (https://gispub.epa.gov/air/trendsreport/2017/#highlights) over North America and Europe in recent decades, and China and India are making concerted efforts to protect the health of their citizen...

The estimation of a monotone trend that has been obscured by stationary fluctuations is considered and illustrated by global temperature anomalies. At an interior point, the rescaled isotonic estimators are shown to converge in distribution to Chernoff’s distribution under minimal conditions on the stationary errors; and two modifications for estimating the value at an end point are compared. T...

Thrombolytic drugs have been used in the clinical arena to treat a wide variety of venous and arterial thromboembolic disorders which are a main cause of death. Thrombolytic molecules are plasminogen activators that convert the inactive plasminogen to the active proteolytic enzyme plasmin which dissolves the blood clot. Fibrin specific plasminoactivators such as tissue – type plasmino activator...

This study of secular trend in Portugal has shown that a positive increment in height occurred in Portuguese 18year-old males between 1904 and 2000, and a secular trend in the age at menarche, towards an earliest age, also took place. Mean height increased 8.93 cm, from 1904 to 2000, when reached 172,13 cm. Besides that, in 2000, statistically significant differences (p ≤ 0.001) among the distr...