Atrial fibrosis is one of the major pathophysiologic mechanisms underlying progression atrial arrhythmias. We previously demonstrated in a swine model that frequent premature complexes (PACs) promote fibrillation (AF) via and slow conduction. Whether such can be reversed or prevented unknown. To evaluate effect (1) PAC eradication (2) antifibrotic drug pirfenidone (PFD) on frequent, dyssynchron...

The method of polarized fluorescence depletion (PFD) has been applied to enhance the resolution of orientational distributions and dynamics obtained from fluorescence polarization (FP) experiments on ordered systems, particularly in muscle fibers. Previous FP data from single fluorescent probes were limited to the 2(nd)- and 4(th)-rank order parameters, and , of...

INTRODUCTION Dense granule (DG) deficiency (DGD) is a feature of some platelet function disorders (PFD) with a prevalence similar to von Willebrand disease. Most laboratories assess for DGD using whole mount platelet preparations and electron microscopy (EM). We evaluated our experiences with this test and associations between DGD and bleeding. METHODS Dense granule EM records for 2006-2017 w...

Chaperone dependency of cancer cells is an emerging trait that relates to the need of transformed cells to cope with the various stresses associated with the malignant state. URI1 (unconventional prefoldin RPB5 interactor 1) encodes a member of the prefoldin (PFD) family of molecular chaperones that acts as part of a heterohexameric PFD complex, the URI1 complex (URI1C), to promote assembly of ...

Phytoplankton, such as diatoms, experience great variations of photon flux density (PFD) and light spectrum along the marine water column. Diatoms have developed some rapidly-regulated photoprotective mechanisms, such as the xanthophyll cycle activation (XC) and the non-photochemical chlorophyll fluorescence quenching (NPQ), to protect themselves from photooxidative damages caused by excess PFD...

Positively frequency-dependent selection is predicted from theory to promote diversity in patchily structured populations and communities, but empirical support for this prediction has been lacking. Here, we investigate frequency-dependent selection among isolates from a local natural population of the highly social bacterium Myxococcus xanthus. Upon starvation, closely related cells of M. xant...

The PFD test was performed on various pancreatic disease patients. The urinary PABA excretion rate was significantly lower in chronic pancreatitis patients and in pancreatic carcinoma patients than in the controls, but no difference was observed between PABA excretion in the two diseases. After surgery, PABA excretion values of pancreatic carcinoma patients were significantly lower than those o...

– This note documents the monolithic power bridge for high-temperature applications implemented within the TERMIS project. This bridge is intended to drive a double-winding Dc brushless motor. The partially depleted 1.0µ µ µ µm-SOI CMOS technology used (X-FAB CI10HS) includes complementary low-voltage MOSFETs, and lateral high-voltage N-channel MOSFETs. The bridge elements (power transistors, s...

Two CAM species, Kalanchoë daigremontiana Hamet et Perrier and Hoya carnosa (L.) R. Br., were grown under a range of five photon flux area densitites (PFD) and then characterized. Significant acclimation to shade was indicated by progressive decreases in leaf thickness, rates of respiratory O(2) uptake, light compensation point, maximum rates of photosynthetic O(2) evolution, nocturnal acid acc...

Estimation of Peak Flood Discharge (PFD) at a desired location on a river is important for planning, design and management of hydraulic structures. This can be achieved through Flood Frequency Analysis (FFA) by fitting of probability distributions to the series of annual maximum discharge data. In the present study, Exponential, Extreme Value Type-1, Extreme Value Type-2, Generalized Pareto and...