Oral drug delivery is the most common route for its convenient and easy administration in Bangladesh. But, it has several limitations such as the hepatic first pass effect, enzymatic degradation and inactivation in gastric environment. Another, hypodermic needles are painful, less convenient and expensive for patients [1]. However, current drug delivery technologies are facilitated by either (t...

A 4.0-kilobase (kb) fragment of Bacillus circulans genomic DNA inserted into pUC19 and encoding endoxylanase activity was subjected to a series of subclonings. A 1.0-kb HindIII-HincII subfragment was found to code for xylanase activity. Maximum expression levels were observed with a subclone that contained an additional 0.3-kb sequence upstream from the coding region. Enhancer sequences in the ...

Addition of skin penetration enhancer in the formulation is the simplest and most common technique to improve transdermal permeation. However chemical penetration enhancers are known to cause skin irritation. In this research project we are proposing natural penetration enhancer (olive oil) based nano-emulsion. The aim of the present study was to investigate the olive oil based nano-emusion for...

The purpose of the present study was to investigate the effect of nanoemulsions as a carrier vehicle of hydrophilic drug for transdermal delivery. The response surface methodology with a mixture design was used to evaluate the effect of ingredient levels of nanoemulsion formulations including cosurfactant (isopropyl alcohol, 20 ∼ 30%), surfactant (mixed of Brij 30 and Brij 35, 20 ∼ 30%), and di...

The current research aims to formulate and evaluated Cinnamaldehyde transdermal patches treat diabetes. A good penetration enhancer Oleic Acid, would improve drug delivery from various polymer-based patches. Transdermal of the matrix type were made by solvent casting techniques using polymer PVP K30, HPMC K100, solvent. All prepared formulations tested for folding endurance, weight variation, t...

A novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan. FTIR spectra showed that arginine was chemically coupled with CS. Elemental analysis estimated that the degrees of substitution (DS) of arginine in CS were 6%, 31.3% and 61.5%, re...

INTRODUCTION Topical glucocorticoids (TG) are the most frequently prescribed drugs by dermatologists. Their clinical effectiveness in the treatment of psoriasis and atopic dermatitis is related to their vasoconstrictive, anti-inflammatory, immunosuppressive and anti-proliferative effects. Despite their benefit in the therapy of inflammatory diseases, TG are associated number of side effects tha...

the purpose of the present study was to explore the passive and electrically assisted transdermal transport of granisetron hydrochloride (gra) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. in this study, iontophoretic permeation of gra through guinea pig skin...

The aim of the present work was to investigate the effects of different surfactants at various concentrations as a skin penetration enhancer through the biomembrane of the shed skin of Naja kaouthia. Additionally, the enhancer mechanism(s) of each class of surfactants were evaluated using physical characterization techniques, such as scanning electron microscopy (SEM), attenuated total reflecta...

Abstract: Aim: The present study aims at exploring the development of xylometazoline hydrochloride loaded chitosan nanoparticles (XYL-NP) cross linked with calcium chloride for treatment nasal congestion. Materials and Methods: XYL-NP were prepared using different polymer like chitosan, linking agent glacial acetic acid as a solvent enhancer ionotropic gelation method, which was further optimiz...