The periodontal ligament stem cells (PDLSCs) are regarded as the promising seed cells for in situ facilitated endogenous periodontal tissue regeneration. Nevertheless the patients with hypervitaminosis A and alcoholism become very difficult to repair periodontal defects and guide bone regeneration. The purpose of this study was to evaluate the effect of all-trans retinoic acid (ATRA) on the rec...

INTRODUCTION Nano-indentation has recently been employed as a powerful tool for determining the mechanical properties of biological tissues on nano and micro scales. A majority of soft biological tissues such as ligaments and tendons exhibit viscoelastic or time-dependent behaviors. The constitutive characterization of soft tissues is among very important subjects in clinical medicine and espec...

We recently developed novel cell transplantation method "cell transfer technology" utilizing photolithography. Using this method, we can transfer ex vivo expanded cells onto scaffold material in desired patterns, like printing of pictures and letters on a paper. We have investigated the possibility of this novel method for cell-based therapy using several disease models. We first transferred en...

Resolution agonists are endogenous mediators that drive inflammation to homeostasis. We earlier demonstrated in vivo activity of resolvins and lipoxins on regenerative periodontal wound healing. The goal of this study was to determine the impact of resolvin D1 (RvD1) on the function of human periodontal ligament (PDL) fibroblasts, which are critical for wound healing during regeneration of the ...

BACKGROUND AND OBJECTIVE A three-dimensional scaffold may play an important role in periodontal tissue engineering. We prepared bio-safe collagen hydrogel, which exhibits properties similar to those of native extracellular matrix. The aim of this study was to examine the effect of implantation of collagen hydrogel/sponge scaffold on periodontal wound healing in class II furcation defects in dog...

Responses of periodontal primary afferents to mechanical stimulation were investigated in an in vitro jaw-nerve preparation from Wistar albino rats. Single unit activities of the inferior alveolar nerve evoked by von Frey stimuli were recorded using the microneurographical technique. Fifty-five (lower incisor) and 100 (lower 3 molars), units responding to spikes of the mechanical stimulation of...

In mechanically loaded tissues such as weight-bearing joints, myocardium, and periodontal ligament, pathophysiological forces can disrupt cell-matrix contacts, which can induce cell death, leading to tissue and organ dysfunction. Protection against force-induced cell death may be mediated by filamin A (FLNa), an actin-binding protein that regulates β1 integrin-mediated cell adhesion. We examine...

Aim: To investigate the expression levels of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) in human periodontal ligament fibroblasts when stimulated with heat in infective conditions. Methods: Periodontal ligament fibroblasts were subjected to various temperature increases for 5 min with or without 10 ng/mL lipopolysaccharide (LPS) and then maintained at 37 ̊C for 6 h. Aft...

Periodontal dokuların bütünlüğünün sağlanması ve korunması için gerekli bir protein olan periostin; periodontal ligament (PDL), iskelet kası, adipoz doku, tendonlar, deri kemik gibi kolajenden zengin bağ dokularında üretilir. Lokalize olduğu yapılardan yola çıkılarak periostinin biyolojik fonksiyonları kardiyovasküler rahatsızlıklar onkoloji alanlarda da incelenmiştir.
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