It is generally accepted that strains of Staphylococcus aureus which are susceptible to penicillin G do not produce beta-lactamase. However, we have found that such a strain susceptible to 0.06 mug of penicillin per ml and 0.56 mug of methicillin per ml produces beta-lactamase(s) which hydrolyzes penicillin G, methicillin, 6-aminopenicillanic acid, and probably cephaloridine. The enzyme which i...

Bacteriological failure with penicillin that has been used widely for years in group A beta hemolytic streptococcal (GABHS) tonsillopharyngitis is being reported as high as 30%. Because of this unresponsiveness, many different agents are being used as alternative options. We evaluated the effect of clarithromycin, amoxicillin/clavulanate (CAM), cefprozil and benzathine penicillin G (Pen G) on t...

Penicillin G acylase from Bacillus megaterium (BmPGA) is currently used in the pharmaceutical industry as an alternative to PGA from Escherichia coli (EcPGA) for the hydrolysis of penicillin G to produce 6-aminopenicillanic acid (6-APA), a penam nucleus for semisynthetic penicillins. Despite the significant differences in amino-acid sequence between PGAs from Gram-positive and Gram-negative bac...

OBJECTIVE To describe the case-fatality rate (CFR) and risk factors of death in children with community-acquired acute pneumonia (CAP) in a pediatric university hospital. METHOD A longitudinal study was developed with prospective data collected from 1996 to 2011. Patients aged 1 month to 12 years were included in the study. Those who left the hospital against medical orders and those transfer...

In the majority of cases of bacterial endocarditis the causal organism is sensitive to benzylpenicillin (Finland and Barnes, I970). Thus this antibiotic is widely used in the treatment of endocarditis and its curative value and low toxicity are well proved. It is common for benzylpenicillin to be given in large doses by the intravenous route for a period of weeks to ensure eradication of the in...

A novel soft-hard cooperative approach was developed to synthesize bioactive mesoporous composite by pre-wrapping Penicillin G amidase with poly(acrylaimde) nanogel skin and subsequently incorporating such Penicillin G amidase nanocapsules into hierarchically mesoporous silica. The as-received bioactive mesoporous composite exhibited comparable activity and extraordinarily high stability in com...

The conductance of solutions of penicillin salts is a governing factor in iontophoretic treatment of infections with this antibiotic. In contrast to the experiments of von Sallmann and Meyer (1) showing an increased transport of penicillin to the aqueous humor of rabbit eyes under a D.C. potential of 45 volts, Hamilton-Paterson (2) states that “penicillin appears to be either a very poor conduc...

The World Health Organization endorses registries as a valuable adjunct to managing rheumatic heart disease (RHD). This study evaluated the management of New Zealand RHD Registry patients from 2010 2019 and alignment Heart Foundation Guidelines. A retrospective audit was undertaken 150 in Tāmaki Makaurau, randomly selected Registry, with review frequency specialist follow-up echocardiograms, do...

this is a report of a case study on 234 patients with impetigo who referred to razi dermatology hospital from april to november, 1989. treatment was started immediately after obtaining direct smear and performing culture and antibiotic sensitivity test. the most common organism responsible for impetigo was the coagulase-positive staphylococcus (71%). in 13.7% of the cases, the coagulase-negativ...