STUDY QUESTION Can independent predictors of pregnancy-associated plasma protein-A (PAPP-A) levels be identified in a group of women who conceived following IVF/ICSI? SUMMARY ANSWER The significantly decreased PAPP-A level in IVF and ICSI pregnancies compared with non-IVF/ICSI pregnancies was correlated strongly with the serum estradiol (E2) level at ovulation triggering. WHAT IS KNOWN ALRE...

The effect of formulation factors on permeation of diclofenac from some experimental and marketed aqueous eye drops through excised goat cornea was evaluated. Raising the pH of formulation from 6.0 to 8.0 or diclofenac concentration from 0.05 to 0.15% (w/v) or adjusting tonicity with mannitol or addition of viscolizing agent decreased apparent permeability coefficient (Papp). Formulation (pH 7....

OBJECTIVES To determine the levels of first-trimester free beta-human chorionic gonadotrophin (free betahCG), pregnancy-associated plasma protein A (PAPP-A) and nuchal translucency (NT) in twin pregnancies. METHODS The study included 93 patients with twin pregnancy and 4,977 with singletons who underwent first-trimester testing using free betahCG, PAPP-A and NT at 10-13 weeks of gestational a...

Background: Prenatal detection of genetic abnormalities is one the biggest challenges current fetal medicine. screening for chromosomal can be done using biochemical tests. The a risk estimation test and not diagnostic test. Methods: Statistical data treatment had been performed on sample 362 pregnant women prenatal screening. This was retrospective analysis study undertaken at National Referen...

BACKGROUND We evaluated patients undergoing percutaneous coronary intervention to assess the predictive value of high-sensitivity C-reactive protein (hs-CRP) and pregnancy-associated plasma protein-A (PAPP-A) on adverse cardiac outcomes and the effect of antiplatelet therapy on these outcomes. METHODS AND RESULTS Baseline blood samples were available on 1468 CREDO (Clopidogrel for the Reducti...

BACKGROUND To study whether maternal serum hyperglycosylated human chorionic gonadotropin (hCG-h) improves first trimester prediction of pre-eclampsia when combined with placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A) and maternal risk factors. METHODS Gestational-age-adjusted concentrations of hCG, hCG-h, PlGF and PAPP-A were analysed in serum samples by time-r...

The age and depositional environment of the Harami Formation were reevaluated based on new larger benthic foraminiferal (LBF) data. LBF assemblage including Orbitoides medius (d'Archiac), O. megaloformis Papp Küpper, gruenbachensis Papp, Pseudomphalocyclus blumenthali Meriç, Omphalocyclus macroporus (Lamarck), Sirtina cf. orbitoidiformis Brönnimann Wirz, Hellenocyclina beotica Reichel, Lepidorb...

The transport of commercially available macrolide antibiotics erythromycin, clarithromycin, roxithromycin, azithromycin, and telithromycin was studied by PAMPA, a model of passive diffusion, and by two models of active transport, Caco-2 and MDCKII-hMDR1. An involvement of efflux pump P-glycoprotein (P-gp) in macrolide transport was also examined. Generally, in Caco-2 and MDCKII-hMDR1 assays wit...

s connected to the Ph.D. thesis Abstracts directly related to the thesis Sas K, Csete K, Vezekényi Z, Vécsei L, Papp JGy. Effect of kynurenine on cerebral circulation of conscious rabbits. Poster. Joint Meeting of the Hungarian and Romanian Societies of Physiological Sciences, Szeged, Abstract Book: p. 31, 1996s directly related to the thesis Sas K, Csete K, Vezekényi Z, Vécsei L, Papp JGy. Eff...

We evaluated the use of multiplex antibody array methodology for simultaneous measurement of serum protein markers for first trimester screening of Down Syndrome (DS) and other pregnancy outcomes such as preeclampsia. For this purpose, we constructed an antibody array for indirect ("sandwich") measurement of seven serum proteins: pregnancy-associated plasma protein-A (PAPP-A), free beta subunit...