The synthesis of a series of chiral PAMAM dendrimers and the formation of chiral dendrimer encapsulated metal nanoparticles are described.

Poly(amidoamine) (PAMAM) dendrimers are hyper-branched polymers with uniform size, defined molecular weight, large internal cavities and a high number of surface groups that make them particularly suitable for a number of biomedical and technological applications [1]. It has been found that surface functionalization is the main factor modulating the toxicity of dendrimers to mammalian cells lin...

PAMAM dendrimers are used as a model system to investigate the effects of counterion condensation and the effective charge for spherical polyelectrolytes. Because of their amino groups, PAMAM dendrimers are weak polyelectrolytes. Lowering the pH results in an increasing protonation of the amino groups which is monitored via the proton chemical shifts of the adjacent CH2 groups. The effective ch...

The development of effective drug delivery systems is a crusial task for modern medicine. main problem the occurrence non-specific toxicity leading to undesirable side effects in vivo. This article aims at reviewing resent research on polyamidoamine (PAMAM) dendrimers results show that PAMAM and modified nanoparticles depends both characteristics particles themselves (size, generation surface c...

Due to the poor compatibility caused by large difference in hydrophilicity and interface between polylactic acid (PLA) cellulose acetate (CA), blending of two materials is difficult application limited. To solve this problem, a type polyamide amine (PAMAM) dendrimer was introduced modify PLA/CA blends work. The results showed that PAMAM could improve blends, promote distribution CA crystallizat...

A human 3D inflammatory cartilage-on-a chip model was develop as a drug screening platform to evaluate the therapeutic efficacy of anti-TNF? mAb-CS/PAMAM dendrimer NPs loaded-Tyramine-Gellan Gum Hydrogel.

The objective of this study was to determine the cytotoxicity, antiproliferative activity, and apoptosis induction activity of two modified glycosides – digoxin and proscillaridin A – conjugated to a generation 3 polyamidoamine dendrimer (G3 PAMAM-NH ) in human breast cancer cells. The results suggest that conjugation with the G3 PAMAM-NH dendrimer enhances the cytotoxicity of modified digoxin ...

The performance of several palladium precatalysts, namely, palladium(II) acetate, palladium(0) nanoparticles encapsulated into poly(amidoamine) (PAMAM) dendrimers (Pd DENs), and palladium(II)-PAMAM complexes, in the Stille reaction between trichloro(phenyl)stannane and iodoarenes in water is compared. The reactivity of Pd DENs is similar or inferior to that of palladium(II) acetate, although th...

Among the six Critical Nanoscale Design Parameters (CNDPs) proposed by Prof. Donald A. Tomalia, this review illustrates the influence of the sixth one, which concerns the elemental composition, on the properties of dendrimers. After a large introduction that summarizes different types of dendrimers that have been compared with PolyAMidoAMine (PAMAM) dendrimers, this review will focus on the pro...