A midline experimental lesion separating the medial longitudinal fasciculi at and below the level of the abducens nuclei without damaging either fasciculus at the level of the nuclei has produced defects of ocular motility resembling those of clinical internuclear ophthalmoplegia. Electromyographic recordings during lateral gaze demonstrate: (1) lack of inhibition of the lateral rectus muscle i...

THE various names given to the condition of ptosis and progressive ophthalmoplegia first described by von Graefe (1868), reflect views regarding the undecided aetiology of this condition, e.g. chronic progressive nuclear ophthalmoplegia, ocular myopathy, progressive muscular dystrophy involving the extra-ocular muscles, etc. M6bius (1900) had named the condition "progressive nuclear ophthalmopl...

To determine the significance of serum anti-GQ1b IgG antibody, we studied the disease spectrum associated with this antibody and GQ1b epitope in the human nervous system. We examined sera from 19 patients with typical Miller Fisher syndrome (MFS), five patients with acute postinfectious ophthalmoplegia without ataxia (atypical MFS), six patients with Guillain-Barré syndrome (GBS) with ophthalmo...

At a recent meeting of the Bath and Bristol Branch of the British Medical Association1 I showed some lantern slides illustrating ptosis, and it has been suggested to me that a short resume of the cases might be of interest to the readers of the Bristol Medico-Chirurgical Journal. The ptosis was symptomatic of ophthalmoplegia externa, and the unusual point was that it came on in middle life in t...

Miller Fisher syndrome is a variant of Guillain-Barre syndrome characterized by the classic triad of ophthalmoplegia, ataxia, and areflexia. Pupillary involvement is common in MFS and has been reported in 35-42% of MFS patients. Although case reports have discussed isolated ophthalmoplegia as a presentation of MFS, anisocoria and rapid fluctuation of pupillary diameter have not been reported in...

To cite: Sánchez Vallejo R, Lopez-Rueda A, Olarte AM, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014206629 DESCRIPTION A 36-year-old man with no medical history, consulted for a 2-week onset right-sided retro-orbital pain associated with diplopia. On neurological examination the patient had combined ipsilateral third and fourth cranial nerve palsy and...