OBJECTIVE Osteoporotic fracture is one of the most common health risks and aggravates the quality of life among postmenopausal women worldwide. In this study, osteoporosis-associated protein biomarkers were identified from urine of osteoporotic female Sprague-Dawley rats developed by ovariectomy. METHOD Four months after the operation, the bone mineral density of the femur of ovariectomized r...

OBJECTIVE We investigated the effect of estrogen therapy on inflammatory responses, cardiovascular functions, and survival in a rat model of heatstroke. DESIGN Controlled, prospective study. SETTING Hospital medical research laboratory. SUBJECTS Sprague-Dawley rats (280-312 g of body weight, males and females). INTERVENTIONS Four major groups of anesthetized rats were designated for exp...

from the right side of the rat were used to determine the radioactivity contained within the mammary teat, fat pad, and vascular areas, while those from the left side were separated into parenchymal cell and fat cell fractions. The intracellular lipid of the parenchymal cells was extracted and quantitated. Although the pattern of carcinogen uptake and clearance by the parenchymal cell intracell...

The present study was designed to investigate the effect Hypericum Perforatum (HP), on behavioral changes, corticosterone, TNF-α levels and tryptophan metabolism and disposition in bilateral ovariectomized rats compared to 17α -ethinylestradiol. Behavioral analysis by measuring immobility time in forced swimming test and open field test, serum and hippocampal corticosterone and TNF-α along with...

Postmenopause is associated with the development of cardiovascular disease, such as hypertension. However, limited information is available regarding effects of exercise on cardiovascular responses and its underlying mechanisms in the simultaneous postmenopausal and hypertensive status. We aimed to investigate whether acute exercise could enhance vasodilation mediated by acetylcholine (ACh) and...