Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) and Glutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia and oral cancer patients and age/sex matched healthy subjects, 25 in each group. Statistically significant (P<0.001) decrease in E-SOD and GPx levels were observed in OSF, oral leukoplakia and oral cancer groups as com...

A case of oral submucous fibrosis in a 12-year-old girl discusses its etiopathogenesis, clinical features, and histopathologic findings of the condition and highlights strong association of areca nut chewing as the potential factor in the etiology of this condition. Cessation of the areca nut chewing habit and submucosal administration of aqueous extract of healthy human placental extract (Plac...

OBJECTIVE To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF). MATERIALS AND METHODS Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied. RESULTS Cells cultured from OSF showed a statistically significant incr...

Premalignant oral lesions are usually associated with noxious oral addiction habits. These habits are common in both, high as well as low socioeconomic status but education status of parent and patients significantly affects the development of noxious oral addictions. A total of 872 patients (cases and controls) were included in the study. Social class was determined as per modified Prasad's cl...

BACKGROUND Oral submucous fibrosis (OSMF) is a chronic debilitating and potentially malignant condition of the oral cavity. It is resistant and progressive affecting the entire oral cavity that sometimes causes a gradual reduction in mouth opening that may even extend up to the pharynx. Although the medical treatment is not completely systematized, optimal doses of its treatment with local inje...

OBJECTIVES Oral submucous fibrosis (OSMF) is the most prevalent precancerous condition in India. Low levels of lipids serves as a marker and prognostic indicator in the early detection of oral precancerous and cancerous states. In spite of the high prevalence and its potential to undergo malignant transformation, this condition has not widely been investigated with respect to the serum lipid le...

Abstract Background Submucous cleft palate (SMCP) is a congenital abnormality with various clinical and anatomical features. pathologies may be unrecognized during routine examinations. Current diagnostic techniques are constrained unrevealing in presurgical patients. This prospective study aimed to evaluate transnasal palatal transillumination technique diagnosis of SMCP at our institute hospi...

There are about 600 million betel quid (BQ) chewers in the world. BQ chewing is associated with increased incidence of oral cancer and submucous fibrosis. In this study, areca nut (AN) extract (200-800 microg/ml) induced the prostaglandin E(2) (PGE(2)) production by 1. 4-3.4-fold and 6-keto-PGF(1 alpha) production by 1.1-1.7-fold of gingival keratinocytes (GK), respectively, following 24 h of e...

Introduction: Oral Submucous fibrosis (OSMF) is well recognized as one of the most common potentially malignant disorder of the oral mucosa in India related to chewing of areca nut products and characterized by mucosal rigidity of varying intensity caused by fibroelastic changes of the juxta – epithelial layer, resulting in a progressive inability to open the mouth. Ultrasonography (USG) is a n...