Substance use is a globally devastating social problem. Early maladaptive schemas (EMSs) are inefficient mechanisms leading directly or indirectly to psychological distress. The current study aimed to assess the role of EMSs in predicting opioid use disorder. The cross-sectional study was conducted in 2013 in Bojnurd at northeast of Iran on 60 male opioid users who received Methadone Maintenanc...

BACKGROUND A substantial proportion of patients with schizophrenia have co-morbid psychoactive substance use, which can influence their cognitive functions. The aim of this study was to assess cognitive functioning in abstinent schizophrenia patients with various previous patterns of psychoactive substance use. MATERIAL/METHODS The study was performed on a group of 80 schizophrenia patients (...

The role of central mu- and kappa-opioid receptors in the regulation of itch sensation was examined using pruritogen-induced mouse scratching behavior model. Intracerebroventricular administration of beta-funaltrexamine, a selective mu-opioid receptor antagonist, inhibited the scratching behavior induced by intradermal substance P, but subcutaneous administration of beta-funaltrexamine did not....

Background Harm reduction, practices that reduce the harms associated with substance abuse without necessarily reducing drug use or consumption, may be a successful strategy to decrease drug-overdose deaths.Types of Studies Reviewed Article reviewed studies and policies focused on harm prescription opioid abuse, medical-dental integration, factors contributing rise in opioid-related deaths.Resu...

BACKGROUND Opioids are used extensively for chronic pain management in the United States. The frequency of opioid use prior to presenting to interventional pain management settings and in interventional pain management settings has been shown to be above 90%. Given that controlled substance abuse and illicit drug use are prevalent phenomena, adherence monitoring of patients that are prescribed ...

This paper reports on changes in substance use and substance dependence symptoms-without intervention-among young adult multidrug users in the club scene, ages 18-29, (N = 444) who participated in a natural history study. Computer-assisted personal interviews at baseline and 6-, 12-, and 18-month follow-ups included well-tested measures of substance use and dependence. Changes in substance depe...

Anesthesia for major head and neck surgery is historically heavily reliant on opioids with deleterious consequences. We reported a case of patient history heroin abuse submitted to tongue carcinoma excision, followed by free-flap reconstruction under opioid-free anesthesia. used propofol total intravenous anesthesia perfusions ketamine, dexmedetomidine, lidocaine, magnesium sulfate analgesia, c...

Background: Prescription drug monitoring programs (PDMPs) are instrumental in controlling opioid misuse,but opioid users have increasingly shifted to cocaine, creating a different set of medical problems. Whileopioid use results in multiple medical comorbidities, findings of the existing studies reported singlecomorbidities rather...

Objectives: Opioid pain medication is most commonly prescribed after distal radius fracture fixation, and there high variability in the quantity duration prescribed. Comorbidities including substance use depression have been associated with higher consumption habits increased sizes of postoperative opioid prescriptions has previously linked to increasing risk chronic disorder. The purpose this ...