Spontaneous hydrolytic deamination of 5-methylcytosine leads to T:G mismatches in double-stranded DNA and comprises a major threat for the integrity of both the DNA primary sequence as well as the epigenetic information stored in the DNA methylation pattern. Failure of the cellular DNA repair machinery to recognize and repair such mismatched nucleotides can lead to a mutator phenotype and subse...

locus of control is a very important issue in the psychological science and it can help people to overcome many psychological disorders. the main assumption of the present study was the relationship between both internal and external locus of control, as a hypothetical variable. the aim of this study was to determine the relationship between locus of control and levels of anxiety in female stud...

Mutants separately resistant to novobiocin, coumermycin, nalidixic acid, and oxolinic acid contained gyrase activity as measured in vitro that was resistant to the antibiotics, indicating that the mutations represented structural alterations of the enzyme. One Novr mutant contained an altered B subunit of the enzyme, as judged by the ability of a plasmid, pNov1, containing the mutation to compl...

in this paper, a new approach is proposed in order to select an optimal membership function for inputs of wind speed prediction system. then using a fuzzy method and the stochastic characteristics of wind speed in the previous year, the wind speed modeling is performed and the wind speed for the future year will be predicted. in this proposed method, the average and the standard deviation of in...

the study aimed to evaluate the correlation of maladjusted schema and locus of control with ocd, with the emphasis on cognitive approach to ocd.in this study, 273 iranian participants were selected; of whom, 30% were male and 70% were female. participants' age ranged from 19 to 34 and the mean age for the sample was 23.42(sd=2.46). participants completed questionnaire batteries including measur...

Many cancers show a low level of microsatellite slippage and are labelled MSI-L (microsatellite instability--low). However, it is unclear whether this slippage can be attributed to some underlying genetic change that results in a mutator phenotype, analogous to mismatch repair deficiency in MSI-H cancers, or whether the apparent instability is the result of relatively frequent normal somatic sl...

Here we describe our study of miRNA isoforms (isomiRs) in breast cancer (BRCA) and normal breast data sets from the Cancer Genome Atlas (TCGA) repository. We report that the full isomiR profiles, from both known and novel human-specific miRNA loci, are particularly rich in information and can distinguish tumor from normal tissue much better than the archetype miRNAs. IsomiR expression is also d...

A new approach for multiple description video coding using motion compensated prediction is proposed. The temporal predictor is designed to provide a desired trade-off between prediction gain and mismatch between the predictions obtained at the encoder and that at the decoder when only one description is available. The mismatch signal is explicitly coded to avoid error propagation. The system c...

Abstract Background and Aims ABO-incompatible kidney transplantation has been associated with an increased risk for antibody-mediated rejection (ABMR) early graft loss attributable to isoagglutinins. Its impact on the development of de novo donor-specific HLA antibodies (DSA) DSA-induced chronic ABMR, however, remains less well studied. Method We analyzed 297 transplant recipients (KTRs) who un...

Fragile X-associated disorders are Repeat Expansion Diseases that result from expansion of a CGG/CCG-repeat in the FMR1 gene. Contractions of the repeat tract also occur, albeit at lower frequency. However, these contractions can potentially modulate disease symptoms or generate an allele with repeat numbers in the normal range. Little is known about the expansion mechanism and even less about ...